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• W2037009006 abstract "Diacylglycerols which activate protein kinase C have the 1,2-sn configuration. Short-chain saturated fatty acids or long-chain unsaturated fatty acids are required for supporting the potency of these lipids. Using alkyl analogs such as 1-O-decyl-2-O-decanoylglycerol, 1-O-decanoyl-2-O-decylglycerol, 1,2-O-didecylglycerol, 1-O-hexadecyl-2-O-acetylglycerol and 1-O-decyl-2-O-acetylglycerol, we showed that the ether bond was consistently associated with a loss of activity to varying extents. The results suggest that the ester bond in the 1-position is a major determinant of diacylglycerol-mediated protein kinase activation." @default.
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• W2037009006 date "1987-06-22" @default.
• W2037009006 modified "2023-10-01" @default.
• W2037009006 title "Alkyl analogs of diacylglycerol as activators of protein kinase C" @default.
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• W2037009006 doi "https://doi.org/10.1016/0014-5793(87)81013-x" @default.
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