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• W2037024816 endingPage "2507" @default.
• W2037024816 startingPage "2473" @default.
• W2037024816 abstract "Iron is a crucial factor for life. However, it also has the potential to cause the formation of noxious free radicals. These double-edged sword characteristics demand a tight regulation of cellular iron metabolism. In this review, we discuss the various pathways of cellular iron uptake, cellular iron storage, and transport. Recent advances in understanding the reduction and uptake of non-transferrin-bound iron are discussed. We also discuss the recent progress in the understanding of transcriptional and translational regulation by iron. Furthermore, we discuss recent advances in the understanding of the regulation of cellular and systemic iron homeostasis and several key diseases resulting from iron deficiency and overload. We also discuss the knockout mice available for studying iron metabolism and the related human conditions. Antioxid. Redox Signal. 18, 2473–2507. I. Introduction II. Uptake of Iron by Mammalian Cells A. Tf-dependent uptake of iron B. Non-Tf-dependent uptake of iron III. Intracellular Transport of Iron A. Iron transport across the enterocyte B. Iron transport across the blood–brain barrier C. Iron transport to mitochondria D. Macrophage-mediated recycling of red cell iron via erythrophagocytosis IV. Intracellular Iron Storage A. Labile iron pool B. Cytoplasmic iron storage C. Mitochondrial iron storage V. Cellular Roles of Iron A. Regulation of transcription by iron B. Post-transcriptional regulation by iron C. Regulation of protein degradation by iron D. Regulation of enzyme activity by iron VI. Regulation of Iron Homeostasis A. Overview of cellular iron homeostasis B. Overview of systemic iron homeostasis 1. Models of systemic iron regulation C. The hepcidin–ferroportin axis and its regulators 1. The pivotal role of hepcidin 2. The HFE/TfR2 pathway 3. The BMP6/HJV pathway VII. Diseases of Iron Metabolism A. Anemias: iron-deficiency anemia, ACD, and IRIDA 1. Iron-deficiency anemia 2. Anemia of chronic disease 3. Iron-refractory iron-deficiency anemia B. Iron overload diseases: the hereditary hemochromatoses and β-thalassemia 1. Hereditary hemochromatosis a. Type 1 HH b. Type 2A HH c. Type 2B HH d. Type 3 HH e. Type 4 HH 2. β-thalassemia VIII. Concluding Remarks" @default.
• W2037024816 created "2016-06-24" @default.
• W2037024816 creator A5074972614 @default.
• W2037024816 creator A5083775667 @default.
• W2037024816 date "2013-06-20" @default.
• W2037024816 modified "2023-10-02" @default.
• W2037024816 title "Mammalian Iron Homeostasis in Health and Disease: Uptake, Storage, Transport, and Molecular Mechanisms of Action" @default.
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