FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037024987> ?p ?o ?g. }

• W2037024987 endingPage "337" @default.
• W2037024987 startingPage "329" @default.
• W2037024987 abstract "The presence of cholesterol has been shown to provide stability and, in general, to decrease the permeability of biological membranes to various solutes. Such stability would be beneficial to the cell only in so far as it does not interfere with specific transport properties. However, recent evidence indicates that if cholesterol concentration within the membranes is increased in relation to phospholipids, vital transport processes could be inhibited. It is proposed that increased incorporation of cholesterol into the plasma membranes of arterial intima cells (possibly induced by high levels of circulating plasma β-lipoproteins and/or endothelial injury), could have a critical inhibitory effect on several important membrane enzymes. Inhibition of regulatory enzymes such as (Na+ + K+)-stimulated ATPase and adenyl cyclase will result in alterations of the metabolic state of the whole cell, initiating a complex sequence of events. Inhibition of the (Na+ + K+) transport ATPase will result in loss of intracellular K+ and consequently to inhibition of protein synthesis and other intracellular enzyme systems, followed by lysis due to osmotic imbalance, and eventual cell death. Impairment of the adenyl cyclase activity and the resulting lower cyclic AMP (cAMP) levels will produce inhibition of several intracellular enzyme systems, including important secretory mechanisms. The accumulation of intracellular esterfied cholesterol, as in fatty streaks, could reflect such inhibition of the mechanism of sterol release. Low levels of cAMP would also tend to induce cell proliferation, as in the early stages of atherogenesis. Cells with impaired transport properties would eventually become necrotic. This would initiate a further sequence of events including proliferation of phagocytes, deposition of lipid plaques, and collagenous fibers, and the other morphological manifestations of advanced atherosclerotic lesions. It is thus possible to derive an etiological relationship between extracellular cholesterol and the latter events related to the development of atherosclerotic lesions." @default.
• W2037024987 created "2016-06-24" @default.
• W2037024987 creator A5016058866 @default.
• W2037024987 date "1974-02-01" @default.
• W2037024987 modified "2023-09-27" @default.
• W2037024987 title "Cholesterol and cell membrane function: A hypothesis concerning the etiology of atherosclerosis" @default.
• W2037024987 cites W119410436 @default.
• W2037024987 cites W1502174044 @default.
• W2037024987 cites W1545132627 @default.
• W2037024987 cites W1560189124 @default.
• W2037024987 cites W1852519544 @default.
• W2037024987 cites W1880399067 @default.
• W2037024987 cites W1954923312 @default.
• W2037024987 cites W1964306346 @default.
• W2037024987 cites W1970104813 @default.
• W2037024987 cites W1973672725 @default.
• W2037024987 cites W1974065280 @default.
• W2037024987 cites W1976168084 @default.
• W2037024987 cites W1980778827 @default.
• W2037024987 cites W1995226155 @default.
• W2037024987 cites W2006715295 @default.
• W2037024987 cites W2006810870 @default.
• W2037024987 cites W2018508736 @default.
• W2037024987 cites W2026303867 @default.
• W2037024987 cites W2030803537 @default.
• W2037024987 cites W2030960955 @default.
• W2037024987 cites W2037353029 @default.
• W2037024987 cites W2039885995 @default.
• W2037024987 cites W2040680978 @default.
• W2037024987 cites W2055425528 @default.
• W2037024987 cites W2056092093 @default.
• W2037024987 cites W2063102921 @default.
• W2037024987 cites W2064586369 @default.
• W2037024987 cites W2069847692 @default.
• W2037024987 cites W2071699489 @default.
• W2037024987 cites W2073594057 @default.
• W2037024987 cites W2077910704 @default.
• W2037024987 cites W2081333375 @default.
• W2037024987 cites W2093104155 @default.
• W2037024987 cites W2098614991 @default.
• W2037024987 cites W2105056427 @default.
• W2037024987 cites W2138042780 @default.
• W2037024987 cites W2143863598 @default.
• W2037024987 cites W2149328563 @default.
• W2037024987 cites W2169542805 @default.
• W2037024987 cites W2322032654 @default.
• W2037024987 cites W2323304304 @default.
• W2037024987 cites W2342991747 @default.
• W2037024987 doi "https://doi.org/10.1016/s0022-5193(74)80064-0" @default.
• W2037024987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4361931" @default.
• W2037024987 hasPublicationYear "1974" @default.
• W2037024987 type Work @default.
• W2037024987 sameAs 2037024987 @default.
• W2037024987 citedByCount "113" @default.
• W2037024987 countsByYear W20370249872014 @default.
• W2037024987 countsByYear W20370249872015 @default.
• W2037024987 countsByYear W20370249872017 @default.
• W2037024987 countsByYear W20370249872018 @default.
• W2037024987 countsByYear W20370249872019 @default.
• W2037024987 countsByYear W20370249872022 @default.
• W2037024987 crossrefType "journal-article" @default.
• W2037024987 hasAuthorship W2037024987A5016058866 @default.
• W2037024987 hasConcept C1491633281 @default.
• W2037024987 hasConcept C181199279 @default.
• W2037024987 hasConcept C23265538 @default.
• W2037024987 hasConcept C2778106830 @default.
• W2037024987 hasConcept C2778163477 @default.
• W2037024987 hasConcept C55493867 @default.
• W2037024987 hasConcept C57409179 @default.
• W2037024987 hasConcept C79879829 @default.
• W2037024987 hasConcept C86803240 @default.
• W2037024987 hasConcept C95444343 @default.
• W2037024987 hasConceptScore W2037024987C1491633281 @default.
• W2037024987 hasConceptScore W2037024987C181199279 @default.
• W2037024987 hasConceptScore W2037024987C23265538 @default.
• W2037024987 hasConceptScore W2037024987C2778106830 @default.
• W2037024987 hasConceptScore W2037024987C2778163477 @default.
• W2037024987 hasConceptScore W2037024987C55493867 @default.
• W2037024987 hasConceptScore W2037024987C57409179 @default.
• W2037024987 hasConceptScore W2037024987C79879829 @default.
• W2037024987 hasConceptScore W2037024987C86803240 @default.
• W2037024987 hasConceptScore W2037024987C95444343 @default.
• W2037024987 hasIssue "2" @default.
• W2037024987 hasLocation W20370249871 @default.
• W2037024987 hasLocation W20370249872 @default.
• W2037024987 hasOpenAccess W2037024987 @default.
• W2037024987 hasPrimaryLocation W20370249871 @default.
• W2037024987 hasRelatedWork W1155355392 @default.
• W2037024987 hasRelatedWork W1504196348 @default.
• W2037024987 hasRelatedWork W2042678520 @default.
• W2037024987 hasRelatedWork W2149828168 @default.
• W2037024987 hasRelatedWork W2159385254 @default.
• W2037024987 hasRelatedWork W2343960475 @default.
• W2037024987 hasRelatedWork W2482787946 @default.
• W2037024987 hasRelatedWork W2606158061 @default.
• W2037024987 hasRelatedWork W4231959386 @default.
• W2037024987 hasRelatedWork W60097589 @default.
• W2037024987 hasVolume "43" @default.

• next