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- W2037028305 abstract "The purpose of this study was to determine the effect of right and septal coronary arterial ligation on ventricular function. Regional myocardial flow was measured using 9 micron radioactive microspheres. Following septal coronary ligation septal flow decreased 45.6% from control; following right coronary arterial ligation right ventricular free wall flow fell 41.2% indicating nearly equivalent degrees of ischemia were produced. Although ventricular systolic pressures and stroke volumes remained stable during septal and right coronary arterial ligations, right ventricular function was significantly depressed as evidenced by a fall in right ventricular peak dP/dt by 19% and 14% respectively, and a significant (P < 0.05) shift in the Frank-Starling function curve to the right. Septal coronary arterial ligation did not cause a significant shift in the left ventricular function curves. Following selective ligation, elevation of aortic pressure significantly increased coronary flow to the septum but failed to increase flow to the right or left ventricular free walls. The fact that left coronary arterial flow failed to increase with greater left ventricular pressure loads indicates loss of coronary autoregulation. This suggests that acute ischemia in one region may result in significant coronary vasoconstriction in a nonischemic region. The acute changes in right ventricular function demonstrate that contraction of the ventricular septum contributes more to right ventricular than left ventricular performance." @default.
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- W2037028305 date "1974-04-01" @default.
- W2037028305 modified "2023-09-26" @default.
- W2037028305 title "ALTERED VENTRICULAR FUNCTION DURING SEPTAL AND RIGHT VENTRICULAR ISCHEMIA IN ANESTHETIZED DOGS" @default.
- W2037028305 doi "https://doi.org/10.1203/00006450-197404000-00054" @default.
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