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- W2037033928 abstract "Rapidly developing proteomic tools are improving detection of deregulated kallikrein‐related peptidase ( KLK ) expression, at the protein level, in prostate and ovarian cancer, as well as facilitating the determination of functional consequences downstream. MS ‐driven proteomics uniquely allows for the detection, identification, and quantification of thousands of proteins in a complex protein pool, and this has served to identify certain KLK s as biomarkers for these diseases. In this review, we describe applications of this technology in KLK biomarker discovery and elucidate MS ‐based techniques that have been used for unbiased, global screening of KLK substrates within complex protein pools. Although MS‐based KLK degradomic studies are limited to date, they helped to discover an array of novel KLK substrates. Substrates identified by MS ‐based degradomics are reported with improved confidence over those determined by incubating a purified or recombinant substrate and protease of interest, in vitro. We propose that these novel proteomic approaches represent the way forward for KLK research, in order to correlate proteolysis of biological substrates with tissue‐related consequences, toward clinical targeting of KLK expression and function for cancer diagnosis, prognosis, and therapies." @default.
- W2037033928 created "2016-06-24" @default.
- W2037033928 creator A5007482524 @default.
- W2037033928 creator A5010374020 @default.
- W2037033928 creator A5016470316 @default.
- W2037033928 creator A5018144880 @default.
- W2037033928 creator A5043670175 @default.
- W2037033928 creator A5045330865 @default.
- W2037033928 creator A5072472360 @default.
- W2037033928 creator A5084743111 @default.
- W2037033928 creator A5090715205 @default.
- W2037033928 date "2014-05-11" @default.
- W2037033928 modified "2023-09-25" @default.
- W2037033928 title "Proteomic and other analyses to determine the functional consequences of deregulated kallikrein-related peptidase (KLK) expression in prostate and ovarian cancer" @default.
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