FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037036408> ?p ?o ?g. }

• W2037036408 endingPage "665" @default.
• W2037036408 startingPage "656" @default.
• W2037036408 abstract "Tobacco smoking is the leading preventable cause of death in the United States. A major negative health consequence of chronic smoking is hypertension. Untoward addictive and cardiovascular sequelae associated with chronic smoking are mediated by nicotine-induced activation of nicotinic receptors (nAChRs) within striatal dopaminergic and hypothalamic noradrenergic systems. Hypertension involves both brain and peripheral angiotensin systems. Activation of angiotensin type-1 receptors (AT1) release dopamine and norepinephrine. The current study determined the role of AT1 and angiotensin type-2 (AT2) receptors in mediating nicotine-evoked dopamine and norepinephrine release from striatal and hypothalamic slices, respectively. The potential involvement of nAChRs in mediating effects of AT1 antagonist losartan and AT2 antagonist, 1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (PD123319) was evaluated by determining their affinities for α4β2* and α7* nAChRs using [³H]nicotine and [³H]methyllycaconitine binding assays, respectively. Results show that losartan concentration-dependently inhibited nicotine-evoked [³H]dopamine and [³H]norepinephrine release (IC₅₀: 3.9 ± 1.2 and 2.2 ± 0.7 μM; Imax: 82 ± 3 and 89 ± 6%, respectively). In contrast, PD123319 did not alter nicotine-evoked norepinephrine release, and potentiated nicotine-evoked dopamine release. These results indicate that AT1 receptors modulate nicotine-evoked striatal dopamine and hypothalamic norepinephrine release. Furthermore, AT1 receptor activation appears to be counteracted by AT2 receptor activation in striatum. Losartan and PD123319 did not inhibit [³H]nicotine or [³H]methyllycaconitine binding, indicating that these AT1 and AT2 antagonists do not interact with the agonist recognition sites on α4β2* and α7* nAChRs to mediate these effects of nicotine. Thus, angiotensin receptors contribute to the effects of nicotine on dopamine and norepinephrine release in brain regions involved in nicotine reward and hypertension." @default.
• W2037036408 created "2016-06-24" @default.
• W2037036408 creator A5018178903 @default.
• W2037036408 creator A5030875271 @default.
• W2037036408 creator A5051628485 @default.
• W2037036408 creator A5056417722 @default.
• W2037036408 creator A5080620160 @default.
• W2037036408 date "2013-09-01" @default.
• W2037036408 modified "2023-10-18" @default.
• W2037036408 title "Angiotensin AT1 and AT2 receptor antagonists modulate nicotine-evoked [3H]dopamine and [3H]norepinephrine release" @default.
• W2037036408 cites W1564465076 @default.
• W2037036408 cites W1571140265 @default.
• W2037036408 cites W1637250296 @default.
• W2037036408 cites W1959467500 @default.
• W2037036408 cites W1963825419 @default.
• W2037036408 cites W1967377740 @default.
• W2037036408 cites W1978702556 @default.
• W2037036408 cites W1984580224 @default.
• W2037036408 cites W1993197471 @default.
• W2037036408 cites W2004164502 @default.
• W2037036408 cites W2010544476 @default.
• W2037036408 cites W2011246896 @default.
• W2037036408 cites W2015853734 @default.
• W2037036408 cites W2025932955 @default.
• W2037036408 cites W2029409221 @default.
• W2037036408 cites W2030648561 @default.
• W2037036408 cites W2034487535 @default.
• W2037036408 cites W2036066421 @default.
• W2037036408 cites W2038608538 @default.
• W2037036408 cites W2039772431 @default.
• W2037036408 cites W2045540781 @default.
• W2037036408 cites W2046806062 @default.
• W2037036408 cites W2048102520 @default.
• W2037036408 cites W2049098433 @default.
• W2037036408 cites W2050666344 @default.
• W2037036408 cites W2056711405 @default.
• W2037036408 cites W2061624095 @default.
• W2037036408 cites W2061992054 @default.
• W2037036408 cites W2063027570 @default.
• W2037036408 cites W2063349406 @default.
• W2037036408 cites W2066848874 @default.
• W2037036408 cites W2074631079 @default.
• W2037036408 cites W2079870772 @default.
• W2037036408 cites W2080357442 @default.
• W2037036408 cites W2080631930 @default.
• W2037036408 cites W2080951265 @default.
• W2037036408 cites W2087199848 @default.
• W2037036408 cites W2089750332 @default.
• W2037036408 cites W2090336026 @default.
• W2037036408 cites W2091296420 @default.
• W2037036408 cites W2095392419 @default.
• W2037036408 cites W2097322630 @default.
• W2037036408 cites W2109518858 @default.
• W2037036408 cites W2113883680 @default.
• W2037036408 cites W2114144700 @default.
• W2037036408 cites W2115872169 @default.
• W2037036408 cites W2140230791 @default.
• W2037036408 cites W2141830709 @default.
• W2037036408 cites W2149065928 @default.
• W2037036408 cites W2154537452 @default.
• W2037036408 cites W2156850243 @default.
• W2037036408 cites W2169817478 @default.
• W2037036408 cites W2225526568 @default.
• W2037036408 cites W2321849281 @default.
• W2037036408 cites W2443896633 @default.
• W2037036408 doi "https://doi.org/10.1016/j.bcp.2013.06.025" @default.
• W2037036408 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4048931" @default.
• W2037036408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23831951" @default.
• W2037036408 hasPublicationYear "2013" @default.
• W2037036408 type Work @default.
• W2037036408 sameAs 2037036408 @default.
• W2037036408 citedByCount "17" @default.
• W2037036408 countsByYear W20370364082013 @default.
• W2037036408 countsByYear W20370364082014 @default.
• W2037036408 countsByYear W20370364082015 @default.
• W2037036408 countsByYear W20370364082016 @default.
• W2037036408 countsByYear W20370364082017 @default.
• W2037036408 countsByYear W20370364082018 @default.
• W2037036408 countsByYear W20370364082019 @default.
• W2037036408 countsByYear W20370364082020 @default.
• W2037036408 countsByYear W20370364082021 @default.
• W2037036408 countsByYear W20370364082022 @default.
• W2037036408 countsByYear W20370364082023 @default.
• W2037036408 crossrefType "journal-article" @default.
• W2037036408 hasAuthorship W2037036408A5018178903 @default.
• W2037036408 hasAuthorship W2037036408A5030875271 @default.
• W2037036408 hasAuthorship W2037036408A5051628485 @default.
• W2037036408 hasAuthorship W2037036408A5056417722 @default.
• W2037036408 hasAuthorship W2037036408A5080620160 @default.
• W2037036408 hasBestOaLocation W20370364082 @default.
• W2037036408 hasConcept C123915805 @default.
• W2037036408 hasConcept C126322002 @default.
• W2037036408 hasConcept C134018914 @default.
• W2037036408 hasConcept C170493617 @default.
• W2037036408 hasConcept C185592680 @default.
• W2037036408 hasConcept C188987157 @default.
• W2037036408 hasConcept C2778514916 @default.
• W2037036408 hasConcept C2779547902 @default.

• next