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- W2037049229 abstract "Pramipexole is a nonergolinic dopamine agonist, with high affinity for the D2 subfamily of dopamine receptors. Pramipexole is efficacious for the symptomatic treatment of early Parkinson’s Disease (PD) and its early use, before that of levodopa can delay the emergence of levodopa-related motor complication. Dosage should be increased gradually from a starting dose of 0.375 mg/day up to a maximum of 4.5 mg/day in equally divided doses taken three times per day with pramipexole immediate-release or equivalent daily dosages once-daily with pramipexole extended-release. Pramipexole can also improve depressive symptoms and possibly health-related quality of life in PD. Nonetheless, its use is not devoid of tolerability problems. While peripheral adverse drug reactions, such as nausea, vomiting or orthostatic hypotension, can be effectively treated and usually pose few problems to most patients, neuropsychiatric events can seriously limit the use of pramipexole in some cases. Indeed, excessive daytime somnolence, impulse-control disorders, hallucinations or delusions can severely affect patients, causing important personal or social handicap. Patients should be informed about the risk of such neuropsychiatric complications and their presence should be actively detected at each consultation. More effort will have to be put into further studying the risk–benefit ratio of pramipexole and other dopamine agonists in the treatment of early PD." @default.
- W2037049229 created "2016-06-24" @default.
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- W2037049229 date "2011-07-01" @default.
- W2037049229 modified "2023-10-18" @default.
- W2037049229 title "Pramipexole for the treatment of early Parkinson’s disease" @default.
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- W2037049229 cites W1977337713 @default.
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- W2037049229 cites W1984432498 @default.
- W2037049229 cites W1986548293 @default.
- W2037049229 cites W1989586415 @default.
- W2037049229 cites W1989848464 @default.
- W2037049229 cites W1998316113 @default.
- W2037049229 cites W2002399254 @default.
- W2037049229 cites W2004434540 @default.
- W2037049229 cites W2006802178 @default.
- W2037049229 cites W2012540611 @default.
- W2037049229 cites W2012557172 @default.
- W2037049229 cites W2014575812 @default.
- W2037049229 cites W2015610659 @default.
- W2037049229 cites W2019300527 @default.
- W2037049229 cites W2020000579 @default.
- W2037049229 cites W2028656651 @default.
- W2037049229 cites W2029086009 @default.
- W2037049229 cites W2030109016 @default.
- W2037049229 cites W2031740174 @default.
- W2037049229 cites W2031917195 @default.
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- W2037049229 cites W2065275335 @default.
- W2037049229 cites W2066514136 @default.
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- W2037049229 cites W2473999118 @default.
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- W2037049229 doi "https://doi.org/10.1586/ern.11.75" @default.
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