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• W2037053607 abstract "Background Two recent clinical studies support the feasibility of trials to evaluate the disease-modifying properties of lithium in Alzheimer's disease, although no benefits were obtained from short-term treatment. Aims To evaluate the effect of long-term lithium treatment on cognitive and biological outcomes in people with amnestic mild cognitive impairment (aMCI). Method Forty-five participants with aMCI were randomised to receive lithium (0.25–0.5 mmol/l) ( n = 24) or placebo ( n = 21) in a 12-month, double-blind trial. Primary outcome measures were the modification of cognitive and functional test scores, and concentrations of cerebrospinal fluid (CSF) biomarkers (amyloid-beta peptide (Aβ 42 ), total tau (T-tau), phosphorylated-tau) (P-tau). Trial registration: NCT01055392. Results Lithium treatment was associated with a significant decrease in CSF concentrations of P-tau ( P = 0.03) and better perform-ance on the cognitive subscale of the Alzheimer's Disease Assessment Scale and in attention tasks. Overall tolerability of lithium was good and the adherence rate was 91%. Conclusions The present data support the notion that lithium has disease-modifying properties with potential clinical implications in the prevention of Alzheimer's disease." @default.
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• W2037053607 date "2011-05-01" @default.
• W2037053607 modified "2023-10-15" @default.
• W2037053607 title "Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial" @default.
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• W2037053607 doi "https://doi.org/10.1192/bjp.bp.110.080044" @default.
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