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- W2037057064 abstract "The inhibitory effect of the dienone-phenolic triterpene, celastrol, on lipid peroxidation in rat liver mitochondrial membranes induced by ADP and Fe2+ was studied. The anti-peroxidative effect of celastrol was very strong: its 50 % inhibitory concentration was 7 μM, and it was about 15 times more effective than α-tocopherol. Celastrol scavenged 1.5 molar equivalents of radicals in homogeneous aqueous ethanolic solution, whereas cysteine and α-tocopherol scavenged one and two molar equivalents of radicals, respectively. The process of anti-peroxidation of celastrol was biphasic, possibly due to stepwise inhibitions of peroxidation in the outer and inner mitochondrial membranes." @default.
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- W2037057064 date "1990-10-01" @default.
- W2037057064 modified "2023-09-29" @default.
- W2037057064 title "The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria" @default.
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- W2037057064 doi "https://doi.org/10.1016/0006-291x(90)90759-g" @default.
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