FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037059265> ?p ?o ?g. }

• W2037059265 endingPage "61" @default.
• W2037059265 startingPage "53" @default.
• W2037059265 abstract "Oxaliplatin is used for treatment of colon cancer in combination with 5-fluorouracil or irinotecan. Oxaliplatin has similar, but also different resistant mechanisms as cisplatin. We studied the activity of oxaliplatin in ovarian and colon cancer cells with different resistance patterns to cisplatin. The 40-fold cisplatin-resistant cell line ADDP was only 7.5-fold resistant to oxaliplatin. The gemcitabine-resistant AG6000 cell line, 9-fold resistant to cisplatin, was not cross-resistant. LoVo-175X2, with mutant p53 showed no resistance compared to the empty vector control. However, LoVo-Li, with inactive p53, was 3.6-fold resistant corresponding to decreased accumulation and Pt adducts. Accumulation and DNA adducts formation showed no significant correlation with oxaliplatin sensitivity. Cell cycle distribution after exposure to oxaliplatin showed arrest in G2/M (A2780) or in S-phase (LoVo-92) for wt-p53 cells. ADDP and LoVo-Li showed G1 arrest followed by S-phase arrest and no changes in distribution, respectively. The cell cycle related proteins Cyclins A and B1 and (p)CDC25C were marginally affected by oxaliplatin. Expression of hCTR1 was decreased in ADDP, LoVo-Li and AG6000, OCT1 decreased in ADDP and AG6000 and OCT3 in LoVo-175X2, compared to the parental cell lines. In ADDP and LoVo-175X2 ATP7A and B were decreased but were increased in AG6000. From this study it can be concluded that changes in cell cycle distribution were cell line dependent and not related to changes in expression of Cyclin A or B1. Oxaliplatin accumulation was related to hCTR1 and, at low concentration, ATP7A to DNA adducts formation while the retention was related to hCTR1, OCT2 and ATP7B." @default.
• W2037059265 created "2016-06-24" @default.
• W2037059265 creator A5001122179 @default.
• W2037059265 creator A5016280722 @default.
• W2037059265 creator A5022690650 @default.
• W2037059265 creator A5035296183 @default.
• W2037059265 creator A5079710895 @default.
• W2037059265 creator A5085422707 @default.
• W2037059265 date "2008-07-01" @default.
• W2037059265 modified "2023-10-17" @default.
• W2037059265 title "Oxaliplatin activity in selected and unselected human ovarian and colorectal cancer cell lines" @default.
• W2037059265 cites W1837926236 @default.
• W2037059265 cites W1963862785 @default.
• W2037059265 cites W1964600217 @default.
• W2037059265 cites W1964821477 @default.
• W2037059265 cites W1966813496 @default.
• W2037059265 cites W1968408143 @default.
• W2037059265 cites W1972245712 @default.
• W2037059265 cites W1986406178 @default.
• W2037059265 cites W1990729534 @default.
• W2037059265 cites W2028062187 @default.
• W2037059265 cites W2031216995 @default.
• W2037059265 cites W2032553799 @default.
• W2037059265 cites W2035114393 @default.
• W2037059265 cites W2039071189 @default.
• W2037059265 cites W2039800013 @default.
• W2037059265 cites W2054814252 @default.
• W2037059265 cites W2063287489 @default.
• W2037059265 cites W2070701697 @default.
• W2037059265 cites W2071337332 @default.
• W2037059265 cites W2072895129 @default.
• W2037059265 cites W2082040301 @default.
• W2037059265 cites W2084540550 @default.
• W2037059265 cites W2097279274 @default.
• W2037059265 cites W2098948686 @default.
• W2037059265 cites W2100128333 @default.
• W2037059265 cites W2100506495 @default.
• W2037059265 cites W2109689528 @default.
• W2037059265 cites W2122023026 @default.
• W2037059265 cites W2135376562 @default.
• W2037059265 cites W2146356730 @default.
• W2037059265 cites W2155568044 @default.
• W2037059265 cites W2156214772 @default.
• W2037059265 cites W2160610387 @default.
• W2037059265 cites W2311663614 @default.
• W2037059265 cites W2316994976 @default.
• W2037059265 doi "https://doi.org/10.1016/j.bcp.2008.04.007" @default.
• W2037059265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18508032" @default.
• W2037059265 hasPublicationYear "2008" @default.
• W2037059265 type Work @default.
• W2037059265 sameAs 2037059265 @default.
• W2037059265 citedByCount "43" @default.
• W2037059265 countsByYear W20370592652012 @default.
• W2037059265 countsByYear W20370592652013 @default.
• W2037059265 countsByYear W20370592652014 @default.
• W2037059265 countsByYear W20370592652015 @default.
• W2037059265 countsByYear W20370592652016 @default.
• W2037059265 countsByYear W20370592652017 @default.
• W2037059265 countsByYear W20370592652018 @default.
• W2037059265 countsByYear W20370592652019 @default.
• W2037059265 countsByYear W20370592652020 @default.
• W2037059265 countsByYear W20370592652021 @default.
• W2037059265 countsByYear W20370592652022 @default.
• W2037059265 countsByYear W20370592652023 @default.
• W2037059265 crossrefType "journal-article" @default.
• W2037059265 hasAuthorship W2037059265A5001122179 @default.
• W2037059265 hasAuthorship W2037059265A5016280722 @default.
• W2037059265 hasAuthorship W2037059265A5022690650 @default.
• W2037059265 hasAuthorship W2037059265A5035296183 @default.
• W2037059265 hasAuthorship W2037059265A5079710895 @default.
• W2037059265 hasAuthorship W2037059265A5085422707 @default.
• W2037059265 hasConcept C121608353 @default.
• W2037059265 hasConcept C126322002 @default.
• W2037059265 hasConcept C1491633281 @default.
• W2037059265 hasConcept C185592680 @default.
• W2037059265 hasConcept C2776694085 @default.
• W2037059265 hasConcept C2778239845 @default.
• W2037059265 hasConcept C2780258809 @default.
• W2037059265 hasConcept C2780259306 @default.
• W2037059265 hasConcept C2780427987 @default.
• W2037059265 hasConcept C2780962732 @default.
• W2037059265 hasConcept C29537977 @default.
• W2037059265 hasConcept C502942594 @default.
• W2037059265 hasConcept C526805850 @default.
• W2037059265 hasConcept C54355233 @default.
• W2037059265 hasConcept C55493867 @default.
• W2037059265 hasConcept C71924100 @default.
• W2037059265 hasConcept C81885089 @default.
• W2037059265 hasConcept C86803240 @default.
• W2037059265 hasConceptScore W2037059265C121608353 @default.
• W2037059265 hasConceptScore W2037059265C126322002 @default.
• W2037059265 hasConceptScore W2037059265C1491633281 @default.
• W2037059265 hasConceptScore W2037059265C185592680 @default.
• W2037059265 hasConceptScore W2037059265C2776694085 @default.
• W2037059265 hasConceptScore W2037059265C2778239845 @default.
• W2037059265 hasConceptScore W2037059265C2780258809 @default.
• W2037059265 hasConceptScore W2037059265C2780259306 @default.
• W2037059265 hasConceptScore W2037059265C2780427987 @default.

• next