Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037060401> ?p ?o ?g. }
- W2037060401 endingPage "6287" @default.
- W2037060401 startingPage "6279" @default.
- W2037060401 abstract "CHD1 encodes an ATP-dependent chromatin remodeler with two chromodomains. Deletion of CHD1 suppresses the temperature-sensitive growth defect caused by mutations in either SPT16 or POB3, which encode subunits of the yFACT chromatin-reorganizing complex. chd1 also suppresses synthetic defects caused by combining an spt16 mutation with other transcription factor mutations, including the synthetic lethality caused by combining an spt16 mutation with TATA binding protein (TBP) or TFIIA defects. Binding of TBP and RNA polymerase II to the GAL1 promoter is reduced in a pob3 mutant, resulting in low levels of GAL1 expression, and all three defects are suppressed by removing Chd1. These results suggest that Chd1 and yFACT have opposing roles in regulating TBP binding at promoters. Additionally, overexpression of Chd1 is tolerated in wild-type cells but is toxic in spt16 mutants. Further, both the ATPase and chromodomain are required for Chd1 activity in opposing yFACT function. Similar to the suppression by chd1, mutations in the SET2 histone methyltransferase also suppress defects caused by yFACT mutations. chd1 and set2 are additive in suppressing pob3, suggesting that Chd1 and Set2 act in distinct pathways. Although human Chd1 has been shown to bind to H3-K4-Me, we discuss evidence arguing that yeast Chd1 binds to neither H3-K4-Me nor H3-K36-Me." @default.
- W2037060401 created "2016-06-24" @default.
- W2037060401 creator A5031756069 @default.
- W2037060401 creator A5034206592 @default.
- W2037060401 creator A5072166104 @default.
- W2037060401 date "2007-09-01" @default.
- W2037060401 modified "2023-09-25" @default.
- W2037060401 title "Chd1 and yFACT Act in Opposition in Regulating Transcription" @default.
- W2037060401 cites W1497947649 @default.
- W2037060401 cites W1554851690 @default.
- W2037060401 cites W1572153680 @default.
- W2037060401 cites W1750603985 @default.
- W2037060401 cites W1832650535 @default.
- W2037060401 cites W1873229374 @default.
- W2037060401 cites W187604509 @default.
- W2037060401 cites W1955280732 @default.
- W2037060401 cites W1967465409 @default.
- W2037060401 cites W1968917541 @default.
- W2037060401 cites W1971196679 @default.
- W2037060401 cites W1972087187 @default.
- W2037060401 cites W1977876594 @default.
- W2037060401 cites W1990713262 @default.
- W2037060401 cites W1992094801 @default.
- W2037060401 cites W1997466838 @default.
- W2037060401 cites W2002085309 @default.
- W2037060401 cites W2002614527 @default.
- W2037060401 cites W2002698073 @default.
- W2037060401 cites W2011847751 @default.
- W2037060401 cites W2012671266 @default.
- W2037060401 cites W2012887640 @default.
- W2037060401 cites W2016603998 @default.
- W2037060401 cites W2025909991 @default.
- W2037060401 cites W2027631710 @default.
- W2037060401 cites W2029394419 @default.
- W2037060401 cites W2034285022 @default.
- W2037060401 cites W2039564969 @default.
- W2037060401 cites W2046306550 @default.
- W2037060401 cites W2049512371 @default.
- W2037060401 cites W2052837845 @default.
- W2037060401 cites W2053524547 @default.
- W2037060401 cites W2058607217 @default.
- W2037060401 cites W2070359888 @default.
- W2037060401 cites W2078622336 @default.
- W2037060401 cites W2079493448 @default.
- W2037060401 cites W2080993511 @default.
- W2037060401 cites W2081322742 @default.
- W2037060401 cites W2084134229 @default.
- W2037060401 cites W2085631727 @default.
- W2037060401 cites W2092668333 @default.
- W2037060401 cites W2093283405 @default.
- W2037060401 cites W2100313737 @default.
- W2037060401 cites W2100716254 @default.
- W2037060401 cites W2102691929 @default.
- W2037060401 cites W2107635128 @default.
- W2037060401 cites W2108707557 @default.
- W2037060401 cites W2123267045 @default.
- W2037060401 cites W2126188271 @default.
- W2037060401 cites W2128542570 @default.
- W2037060401 cites W2133858902 @default.
- W2037060401 cites W2135869142 @default.
- W2037060401 cites W2139400144 @default.
- W2037060401 cites W2139548742 @default.
- W2037060401 cites W2143617365 @default.
- W2037060401 cites W2143756387 @default.
- W2037060401 cites W2144888197 @default.
- W2037060401 cites W2150521128 @default.
- W2037060401 cites W2150858423 @default.
- W2037060401 cites W2152531069 @default.
- W2037060401 cites W2160709235 @default.
- W2037060401 cites W2166023249 @default.
- W2037060401 cites W2167284666 @default.
- W2037060401 cites W2171899776 @default.
- W2037060401 cites W2172290898 @default.
- W2037060401 cites W40230220 @default.
- W2037060401 cites W4240065971 @default.
- W2037060401 doi "https://doi.org/10.1128/mcb.00978-07" @default.
- W2037060401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2099615" @default.
- W2037060401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17620414" @default.
- W2037060401 hasPublicationYear "2007" @default.
- W2037060401 type Work @default.
- W2037060401 sameAs 2037060401 @default.
- W2037060401 citedByCount "35" @default.
- W2037060401 countsByYear W20370604012012 @default.
- W2037060401 countsByYear W20370604012013 @default.
- W2037060401 countsByYear W20370604012014 @default.
- W2037060401 countsByYear W20370604012015 @default.
- W2037060401 countsByYear W20370604012016 @default.
- W2037060401 countsByYear W20370604012017 @default.
- W2037060401 countsByYear W20370604012018 @default.
- W2037060401 countsByYear W20370604012019 @default.
- W2037060401 countsByYear W20370604012020 @default.
- W2037060401 countsByYear W20370604012021 @default.
- W2037060401 countsByYear W20370604012022 @default.
- W2037060401 crossrefType "journal-article" @default.
- W2037060401 hasAuthorship W2037060401A5031756069 @default.
- W2037060401 hasAuthorship W2037060401A5034206592 @default.
- W2037060401 hasAuthorship W2037060401A5072166104 @default.
- W2037060401 hasBestOaLocation W20370604011 @default.