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- W2037076199 abstract "We investigate the effect of rosiglitazone, a ligand for peroxisome proliferator-activated receptor-γ (PPARγ) with anti-inflammatory and anti-oxidative actions, on hippocampal injury and its roles in mitochondrial uncoupling protein 2 (UCP2) expression caused by transient global ischemia (TGI) in rats. Increased UCP2 expression was observed in mitochondria of hippocampal CA1 2–24 h after TGI/reperfusion, with maximal expression levels at 6–18 h. Administration of rosiglitazone to hippocampus 30 min prior to the onset of TGI further enhanced mitochondrial UCP2 expression 2–6 h following TGI/reperfusion. Rats subjected to TGI/reperfusion displayed a significant increase in lipid peroxidation, based on increased malondialdehyde (MDA) levels, in hippocampal CA1 mitochondria 2–6 h after reperfusion. Rosiglitazone significantly attenuated TGI/reperfusion-induced lipid peroxidation and suppressed hippocampal CA1 neuronal death based on the surviving neuronal counts. In conclusion, our results provide correlative evidence for the “PPARγ → UCP2 → neuroprotection” cascade in ischemic brain injury." @default.
- W2037076199 created "2016-06-24" @default.
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- W2037076199 date "2006-12-01" @default.
- W2037076199 modified "2023-10-11" @default.
- W2037076199 title "Effects of rosiglitazone on global ischemia-induced hippocampal injury and expression of mitochondrial uncoupling protein 2" @default.
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- W2037076199 doi "https://doi.org/10.1016/j.bbrc.2006.10.017" @default.
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