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- W2037108296 abstract "In the perfused mesenteric artery of the rat phynylephrine produced a concentration-dependent increase in perfusion pressure which was competitively antagonized by low concentrations of prazosin (pA2 9.56). Guanfacine, clonidine and guanabenz, three α2-selective agonists, produced no response. However, guanabenz antagonized the phenylephrine-induced effect competitively (pA2 6.92) though guanfacine and clonidine did not affect it. These results suggest that the α2-adrenergic agonist guanabenz possesses α1-antagonist activity as well." @default.
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- W2037108296 date "1984-08-01" @default.
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- W2037108296 title "α1-antagonist activity of the α2-adrenoceptor agonist guanabenz in perfused mesenteric artery of the rat" @default.
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- W2037108296 doi "https://doi.org/10.1016/0014-2999(84)90207-3" @default.
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