FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037109214> ?p ?o ?g. }

• W2037109214 endingPage "256" @default.
• W2037109214 startingPage "256" @default.
• W2037109214 abstract "We assessed cytotoxicity of X rays or fission neutrons and the status of the p53 tumor suppressor gene in irradiated and unirradiated actively growing cultures of human breast cancer MCF-7 cells. One parental or wild-type (WT) and the other resistant to adriamycin (ADRR) were studied within the same experiment. We found that, relative to MCF-7 WT cells, MCF-7 ADRR cells exhibited a small but significant resistance to X rays, but not to fission neutrons. Single-strand conformation polymorphism analysis followed by DNA sequencing and immunohistochemical staining with a p53 protein-specific antibody performed on pooled polyclonal or monoclonal populations of MCF-7 WT or ADRR cells confirmed that wild-type cells have two normal copies of the p53 gene. We discovered p53 loss of heterozygosity and a point mutation in the remaining allele of the p53 gene in adriamycin-resistant cells. This mutation is a splice acceptor site change on the upstream border of exon 5 and results in p53 protein overexpression. No new p53 mutations were observed in MCF-7 WT or ADRR cells surviving either X or fission-neutron irradiations. Our results suggest that the mutant p53 allele affects cytotoxic outcomes of DNA damage from X rays but not from neutrons." @default.
• W2037109214 created "2016-06-24" @default.
• W2037109214 creator A5001064189 @default.
• W2037109214 creator A5020414889 @default.
• W2037109214 creator A5024270187 @default.
• W2037109214 creator A5033696694 @default.
• W2037109214 creator A5036129407 @default.
• W2037109214 creator A5045379466 @default.
• W2037109214 date "1995-06-01" @default.
• W2037109214 modified "2023-10-14" @default.
• W2037109214 title "p53 Mutational Status and Survival of Human Breast Cancer MCF-7 Cell Variants after Exposure to X Rays or Fission Neutrons" @default.
• W2037109214 cites W14359987 @default.
• W2037109214 cites W1480986388 @default.
• W2037109214 cites W1482690359 @default.
• W2037109214 cites W1505025572 @default.
• W2037109214 cites W1517399586 @default.
• W2037109214 cites W1524240242 @default.
• W2037109214 cites W1572790077 @default.
• W2037109214 cites W1628906992 @default.
• W2037109214 cites W1849359401 @default.
• W2037109214 cites W1978881929 @default.
• W2037109214 cites W1985849437 @default.
• W2037109214 cites W1986179131 @default.
• W2037109214 cites W1986685145 @default.
• W2037109214 cites W1996027687 @default.
• W2037109214 cites W2008852784 @default.
• W2037109214 cites W2011727075 @default.
• W2037109214 cites W2012053348 @default.
• W2037109214 cites W2013609629 @default.
• W2037109214 cites W2015519364 @default.
• W2037109214 cites W2023096907 @default.
• W2037109214 cites W2035035052 @default.
• W2037109214 cites W2038660406 @default.
• W2037109214 cites W2040699587 @default.
• W2037109214 cites W2040978030 @default.
• W2037109214 cites W2042316019 @default.
• W2037109214 cites W2055078984 @default.
• W2037109214 cites W2055280366 @default.
• W2037109214 cites W2067722023 @default.
• W2037109214 cites W2070854644 @default.
• W2037109214 cites W2072564410 @default.
• W2037109214 cites W2076149108 @default.
• W2037109214 cites W2081969062 @default.
• W2037109214 cites W2082157165 @default.
• W2037109214 cites W2089218510 @default.
• W2037109214 cites W2090020958 @default.
• W2037109214 cites W2090025028 @default.
• W2037109214 cites W2092137728 @default.
• W2037109214 cites W2098567881 @default.
• W2037109214 cites W2100964039 @default.
• W2037109214 cites W2104647576 @default.
• W2037109214 cites W2118277449 @default.
• W2037109214 cites W2123423958 @default.
• W2037109214 cites W2149535267 @default.
• W2037109214 cites W2151242353 @default.
• W2037109214 cites W2154287891 @default.
• W2037109214 cites W2167597785 @default.
• W2037109214 cites W2181681964 @default.
• W2037109214 cites W2317432992 @default.
• W2037109214 cites W2322301164 @default.
• W2037109214 cites W2330520802 @default.
• W2037109214 cites W2397735695 @default.
• W2037109214 cites W2405173083 @default.
• W2037109214 cites W2412677958 @default.
• W2037109214 cites W2444090053 @default.
• W2037109214 cites W2471509359 @default.
• W2037109214 cites W3119939690 @default.
• W2037109214 cites W3148901782 @default.
• W2037109214 cites W1594987216 @default.
• W2037109214 doi "https://doi.org/10.2307/3579133" @default.
• W2037109214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7761574" @default.
• W2037109214 hasPublicationYear "1995" @default.
• W2037109214 type Work @default.
• W2037109214 sameAs 2037109214 @default.
• W2037109214 citedByCount "41" @default.
• W2037109214 countsByYear W20371092142012 @default.
• W2037109214 countsByYear W20371092142015 @default.
• W2037109214 countsByYear W20371092142020 @default.
• W2037109214 countsByYear W20371092142022 @default.
• W2037109214 crossrefType "journal-article" @default.
• W2037109214 hasAuthorship W2037109214A5001064189 @default.
• W2037109214 hasAuthorship W2037109214A5020414889 @default.
• W2037109214 hasAuthorship W2037109214A5024270187 @default.
• W2037109214 hasAuthorship W2037109214A5033696694 @default.
• W2037109214 hasAuthorship W2037109214A5036129407 @default.
• W2037109214 hasAuthorship W2037109214A5045379466 @default.
• W2037109214 hasConcept C104317684 @default.
• W2037109214 hasConcept C109541995 @default.
• W2037109214 hasConcept C121608353 @default.
• W2037109214 hasConcept C143065580 @default.
• W2037109214 hasConcept C143589142 @default.
• W2037109214 hasConcept C153911025 @default.
• W2037109214 hasConcept C176944494 @default.
• W2037109214 hasConcept C180754005 @default.
• W2037109214 hasConcept C2778264664 @default.
• W2037109214 hasConcept C2994423619 @default.
• W2037109214 hasConcept C36823959 @default.
• W2037109214 hasConcept C502942594 @default.

• next