Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037112367> ?p ?o ?g. }
- W2037112367 endingPage "317" @default.
- W2037112367 startingPage "313" @default.
- W2037112367 abstract "The γ polypeptide of brain G‐proteins is carboxyl methylated when the purified βγ subunit complex is reconstituted with S‐adenosyl‐[ 3 H‐methyl]‐L‐methionine and a methyltransferase present in detergent‐stripped brain membranes. By Chromatographic analysis of the 3 H‐amino acid generated by exhaustive proteolysis and performic acid oxidation of the 3 H‐methylated βγ complex, we show that this modification occurs on the α‐carboxyl group of a C‐terminal cysteine residue. Our result suggests that brain G‐proteins may undergo multiple covalent modification steps, including proteolytic removal of the three terminal amino acids from the predicted common C‐terminal Cys‐Xaa‐Xaa‐Xaa sequence, and the methyl esterification of the resulting terminal cysteine residue. This modification is likely to be associated with lipidation at the sulfhydryl group of the same cysteine, which would explain the tight membrane binding property of the brain βγ complex." @default.
- W2037112367 created "2016-06-24" @default.
- W2037112367 creator A5001766757 @default.
- W2037112367 creator A5039947475 @default.
- W2037112367 creator A5087007675 @default.
- W2037112367 creator A5090650225 @default.
- W2037112367 date "1990-01-29" @default.
- W2037112367 modified "2023-09-25" @default.
- W2037112367 title "The γ subunit of brain G-proteins is methyl esterified at a C-terminal cysteine" @default.
- W2037112367 cites W1480719130 @default.
- W2037112367 cites W1481859953 @default.
- W2037112367 cites W1499138436 @default.
- W2037112367 cites W1509164711 @default.
- W2037112367 cites W1527774170 @default.
- W2037112367 cites W1533101741 @default.
- W2037112367 cites W1550872707 @default.
- W2037112367 cites W1554275806 @default.
- W2037112367 cites W1557240819 @default.
- W2037112367 cites W1560820482 @default.
- W2037112367 cites W1566050966 @default.
- W2037112367 cites W1569033208 @default.
- W2037112367 cites W1570939625 @default.
- W2037112367 cites W1600252058 @default.
- W2037112367 cites W1639281802 @default.
- W2037112367 cites W1702339793 @default.
- W2037112367 cites W1965404955 @default.
- W2037112367 cites W1975085160 @default.
- W2037112367 cites W1979591208 @default.
- W2037112367 cites W2000115325 @default.
- W2037112367 cites W2003267467 @default.
- W2037112367 cites W2016002808 @default.
- W2037112367 cites W2023207364 @default.
- W2037112367 cites W2036584166 @default.
- W2037112367 cites W2041014178 @default.
- W2037112367 cites W2052720758 @default.
- W2037112367 cites W2058004531 @default.
- W2037112367 cites W207418012 @default.
- W2037112367 cites W2080875376 @default.
- W2037112367 cites W2100837269 @default.
- W2037112367 cites W2131547839 @default.
- W2037112367 cites W2133362776 @default.
- W2037112367 cites W2176699929 @default.
- W2037112367 cites W4293247451 @default.
- W2037112367 cites W4323285289 @default.
- W2037112367 doi "https://doi.org/10.1016/0014-5793(90)80132-3" @default.
- W2037112367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2105241" @default.
- W2037112367 hasPublicationYear "1990" @default.
- W2037112367 type Work @default.
- W2037112367 sameAs 2037112367 @default.
- W2037112367 citedByCount "59" @default.
- W2037112367 countsByYear W20371123672017 @default.
- W2037112367 crossrefType "journal-article" @default.
- W2037112367 hasAuthorship W2037112367A5001766757 @default.
- W2037112367 hasAuthorship W2037112367A5039947475 @default.
- W2037112367 hasAuthorship W2037112367A5087007675 @default.
- W2037112367 hasAuthorship W2037112367A5090650225 @default.
- W2037112367 hasConcept C104292427 @default.
- W2037112367 hasConcept C104317684 @default.
- W2037112367 hasConcept C167625842 @default.
- W2037112367 hasConcept C178790620 @default.
- W2037112367 hasConcept C180577832 @default.
- W2037112367 hasConcept C181199279 @default.
- W2037112367 hasConcept C185592680 @default.
- W2037112367 hasConcept C190283241 @default.
- W2037112367 hasConcept C193469717 @default.
- W2037112367 hasConcept C203522944 @default.
- W2037112367 hasConcept C2776414213 @default.
- W2037112367 hasConcept C2778432551 @default.
- W2037112367 hasConcept C2779201268 @default.
- W2037112367 hasConcept C2780912031 @default.
- W2037112367 hasConcept C2781307694 @default.
- W2037112367 hasConcept C2781338088 @default.
- W2037112367 hasConcept C515207424 @default.
- W2037112367 hasConcept C55493867 @default.
- W2037112367 hasConcept C71240020 @default.
- W2037112367 hasConceptScore W2037112367C104292427 @default.
- W2037112367 hasConceptScore W2037112367C104317684 @default.
- W2037112367 hasConceptScore W2037112367C167625842 @default.
- W2037112367 hasConceptScore W2037112367C178790620 @default.
- W2037112367 hasConceptScore W2037112367C180577832 @default.
- W2037112367 hasConceptScore W2037112367C181199279 @default.
- W2037112367 hasConceptScore W2037112367C185592680 @default.
- W2037112367 hasConceptScore W2037112367C190283241 @default.
- W2037112367 hasConceptScore W2037112367C193469717 @default.
- W2037112367 hasConceptScore W2037112367C203522944 @default.
- W2037112367 hasConceptScore W2037112367C2776414213 @default.
- W2037112367 hasConceptScore W2037112367C2778432551 @default.
- W2037112367 hasConceptScore W2037112367C2779201268 @default.
- W2037112367 hasConceptScore W2037112367C2780912031 @default.
- W2037112367 hasConceptScore W2037112367C2781307694 @default.
- W2037112367 hasConceptScore W2037112367C2781338088 @default.
- W2037112367 hasConceptScore W2037112367C515207424 @default.
- W2037112367 hasConceptScore W2037112367C55493867 @default.
- W2037112367 hasConceptScore W2037112367C71240020 @default.
- W2037112367 hasIssue "2" @default.
- W2037112367 hasLocation W20371123671 @default.
- W2037112367 hasLocation W20371123672 @default.
- W2037112367 hasOpenAccess W2037112367 @default.