FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037112704> ?p ?o ?g. }

• W2037112704 endingPage "1497" @default.
• W2037112704 startingPage "1490" @default.
• W2037112704 abstract "Reliable diagnosis of traumatic brain injury (TBI) is a major public health need. Glial fibrillary acidic protein (GFAP) is expressed in the central nervous system, and breakdown products (GFAP-BDP) are released following parenchymal brain injury. Here, we evaluate the diagnostic accuracy of elevated levels of plasma GFAP-BDP in TBI. Participants were identified as part of the prospective Transforming Research And Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Study. Acute plasma samples (<24 h post-injury) were collected from patients presenting with brain injury who had CT imaging. The ability of GFAP-BDP level to discriminate patients with demonstrable traumatic lesions on CT, and with failure to return to pre-injury baseline at 6 months, was evaluated by the area under the receiver operating characteristic curve (AUC). Of the 215 patients included for analysis, 83% had mild, 4% had moderate, and 13% had severe TBI; 54% had acute traumatic lesions on CT. The ability of GFAP-BDP level to discriminate patients with traumatic lesions on CT as evaluated by AUC was 0.88 (95% confidence interval [CI], 0.84–0.93). The optimal cutoff of 0.68 ng/mL for plasma GFAP-BDP level was associated with a 21.61 odds ratio for traumatic findings on head CT. Discriminatory ability of unfavorable 6 month outcome was lower, AUC 0.65 (95% CI, 0.55–0.74), with a 2.07 odds ratio. GFAP-BDP levels reliably distinguish the presence and severity of CT scan findings in TBI patients. Although these findings confirm and extend prior studies, a larger prospective trial is still needed to validate the use of GFAP-BDP as a routine diagnostic biomarker for patient care and clinical research. The term “mild” continues to be a misnomer for this patient population, and underscores the need for evolving classification strategies for TBI targeted therapy. (ClinicalTrials.gov number NCT01565551; NIH Grant 1RC2 NS069409)" @default.
• W2037112704 created "2016-06-24" @default.
• W2037112704 creator A5001050274 @default.
• W2037112704 creator A5010996988 @default.
• W2037112704 creator A5016270829 @default.
• W2037112704 creator A5026647662 @default.
• W2037112704 creator A5030104217 @default.
• W2037112704 creator A5030926003 @default.
• W2037112704 creator A5031038037 @default.
• W2037112704 creator A5032006164 @default.
• W2037112704 creator A5033670596 @default.
• W2037112704 creator A5044174824 @default.
• W2037112704 creator A5047432893 @default.
• W2037112704 creator A5056459555 @default.
• W2037112704 creator A5057778218 @default.
• W2037112704 creator A5058619000 @default.
• W2037112704 creator A5059222028 @default.
• W2037112704 creator A5059966257 @default.
• W2037112704 creator A5065855561 @default.
• W2037112704 creator A5067164175 @default.
• W2037112704 creator A5074176694 @default.
• W2037112704 creator A5076261073 @default.
• W2037112704 creator A5084063845 @default.
• W2037112704 creator A5084720115 @default.
• W2037112704 creator A5087748936 @default.
• W2037112704 creator A5088649612 @default.
• W2037112704 date "2013-09-01" @default.
• W2037112704 modified "2023-10-14" @default.
• W2037112704 title "GFAP-BDP as an Acute Diagnostic Marker in Traumatic Brain Injury: Results from the Prospective Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study" @default.
• W2037112704 cites W1965155730 @default.
• W2037112704 cites W1966439088 @default.
• W2037112704 cites W1972491904 @default.
• W2037112704 cites W1975473823 @default.
• W2037112704 cites W1988816170 @default.
• W2037112704 cites W1993701288 @default.
• W2037112704 cites W2008388727 @default.
• W2037112704 cites W2010141872 @default.
• W2037112704 cites W2020030788 @default.
• W2037112704 cites W2027667780 @default.
• W2037112704 cites W2030443964 @default.
• W2037112704 cites W2033297074 @default.
• W2037112704 cites W2051440255 @default.
• W2037112704 cites W2058042345 @default.
• W2037112704 cites W2079839117 @default.
• W2037112704 cites W2080063376 @default.
• W2037112704 cites W2083996703 @default.
• W2037112704 cites W2085766999 @default.
• W2037112704 cites W2086108288 @default.
• W2037112704 cites W2089686273 @default.
• W2037112704 cites W2092703451 @default.
• W2037112704 cites W2098002403 @default.
• W2037112704 cites W2099339447 @default.
• W2037112704 cites W2116075855 @default.
• W2037112704 cites W2124911240 @default.
• W2037112704 cites W2137004142 @default.
• W2037112704 cites W2141188392 @default.
• W2037112704 cites W2154289778 @default.
• W2037112704 cites W2155038264 @default.
• W2037112704 cites W2169828275 @default.
• W2037112704 cites W2171395319 @default.
• W2037112704 cites W27664858 @default.
• W2037112704 doi "https://doi.org/10.1089/neu.2013.2883" @default.
• W2037112704 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3751263" @default.
• W2037112704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23489259" @default.
• W2037112704 hasPublicationYear "2013" @default.
• W2037112704 type Work @default.
• W2037112704 sameAs 2037112704 @default.
• W2037112704 citedByCount "154" @default.
• W2037112704 countsByYear W20371127042013 @default.
• W2037112704 countsByYear W20371127042014 @default.
• W2037112704 countsByYear W20371127042015 @default.
• W2037112704 countsByYear W20371127042016 @default.
• W2037112704 countsByYear W20371127042017 @default.
• W2037112704 countsByYear W20371127042018 @default.
• W2037112704 countsByYear W20371127042019 @default.
• W2037112704 countsByYear W20371127042020 @default.
• W2037112704 countsByYear W20371127042021 @default.
• W2037112704 countsByYear W20371127042022 @default.
• W2037112704 countsByYear W20371127042023 @default.
• W2037112704 crossrefType "journal-article" @default.
• W2037112704 hasAuthorship W2037112704A5001050274 @default.
• W2037112704 hasAuthorship W2037112704A5010996988 @default.
• W2037112704 hasAuthorship W2037112704A5016270829 @default.
• W2037112704 hasAuthorship W2037112704A5026647662 @default.
• W2037112704 hasAuthorship W2037112704A5030104217 @default.
• W2037112704 hasAuthorship W2037112704A5030926003 @default.
• W2037112704 hasAuthorship W2037112704A5031038037 @default.
• W2037112704 hasAuthorship W2037112704A5032006164 @default.
• W2037112704 hasAuthorship W2037112704A5033670596 @default.
• W2037112704 hasAuthorship W2037112704A5044174824 @default.
• W2037112704 hasAuthorship W2037112704A5047432893 @default.
• W2037112704 hasAuthorship W2037112704A5056459555 @default.
• W2037112704 hasAuthorship W2037112704A5057778218 @default.
• W2037112704 hasAuthorship W2037112704A5058619000 @default.
• W2037112704 hasAuthorship W2037112704A5059222028 @default.
• W2037112704 hasAuthorship W2037112704A5059966257 @default.
• W2037112704 hasAuthorship W2037112704A5065855561 @default.
• W2037112704 hasAuthorship W2037112704A5067164175 @default.

• next