Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037114191> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2037114191 endingPage "35" @default.
- W2037114191 startingPage "23" @default.
- W2037114191 abstract "Arildone (4-[6-(2-chloro-4-methoxyphenoxy)hexyl] -3,5-heptanedione is a selective inhibitor of poliovirus uncoating. We have isolated an arildone-resistant poliovirus 2 variant and characterized it. In single cycle growth curve experiments the resistant virus was not influenced by 1 microgram/ml of arildone, which completely inhibited the replication of the sensitive virus. In neutralization experiments the rates of inactivation vs time of the parent and the resistant virus proved indistinguishable. The adsorption behavior of the mutant closely resembled that of the wild-type. Uncoating as measured with neutral red-sensitized arildone-resistant mutant virus was unaffected by arildone, in contrast to the uncoating of the sensitive parent virus. It has been previously shown that arildone stabilizes the poliovirus capsid from alkaline degradation. The arildone-resistant mutant, however, was not markedly stabilized by the drug under these conditions. No difference in thermostability between mutant and parent virus could be detected. In isoelectric focusing the sensitive virus exhibited 2 peaks, but in the presence of arildone only one peak was apparent. In contrast, the arildone-resistant virus remained unaffected by the presence of arildone. Analysis of the capsid proteins of the sensitive parent and the resistant virus in SDS-polyacrylamide gels revealed no difference in the patterns; however, peptide mapping showed clear differences in VP1." @default.
- W2037114191 created "2016-06-24" @default.
- W2037114191 creator A5014989436 @default.
- W2037114191 creator A5080096449 @default.
- W2037114191 date "1988-01-01" @default.
- W2037114191 modified "2023-09-27" @default.
- W2037114191 title "Isolation and characterization of an arildone-resistant poliovirus 2 mutant with an altered capsid protein VP1" @default.
- W2037114191 cites W1507076005 @default.
- W2037114191 cites W1970651127 @default.
- W2037114191 cites W1985771599 @default.
- W2037114191 cites W1986459417 @default.
- W2037114191 cites W1986573957 @default.
- W2037114191 cites W1988989701 @default.
- W2037114191 cites W1999643808 @default.
- W2037114191 cites W2007070703 @default.
- W2037114191 cites W2017570406 @default.
- W2037114191 cites W2037190079 @default.
- W2037114191 cites W2037263249 @default.
- W2037114191 cites W2039628138 @default.
- W2037114191 cites W2042867550 @default.
- W2037114191 cites W2050264107 @default.
- W2037114191 cites W2052037808 @default.
- W2037114191 cites W2057376979 @default.
- W2037114191 cites W2060445441 @default.
- W2037114191 cites W2060520834 @default.
- W2037114191 cites W2074858827 @default.
- W2037114191 cites W2084352383 @default.
- W2037114191 cites W2085172136 @default.
- W2037114191 cites W2089960033 @default.
- W2037114191 cites W2091791004 @default.
- W2037114191 cites W2093244394 @default.
- W2037114191 cites W2100837269 @default.
- W2037114191 cites W2107351598 @default.
- W2037114191 cites W2161102322 @default.
- W2037114191 cites W2164358316 @default.
- W2037114191 cites W2415422935 @default.
- W2037114191 cites W89772331 @default.
- W2037114191 doi "https://doi.org/10.1016/0166-3542(88)90064-2" @default.
- W2037114191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2839108" @default.
- W2037114191 hasPublicationYear "1988" @default.
- W2037114191 type Work @default.
- W2037114191 sameAs 2037114191 @default.
- W2037114191 citedByCount "15" @default.
- W2037114191 countsByYear W20371141912013 @default.
- W2037114191 countsByYear W20371141912014 @default.
- W2037114191 countsByYear W20371141912015 @default.
- W2037114191 crossrefType "journal-article" @default.
- W2037114191 hasAuthorship W2037114191A5014989436 @default.
- W2037114191 hasAuthorship W2037114191A5080096449 @default.
- W2037114191 hasConcept C104317684 @default.
- W2037114191 hasConcept C143065580 @default.
- W2037114191 hasConcept C153911025 @default.
- W2037114191 hasConcept C159047783 @default.
- W2037114191 hasConcept C181199279 @default.
- W2037114191 hasConcept C185592680 @default.
- W2037114191 hasConcept C202878990 @default.
- W2037114191 hasConcept C2522874641 @default.
- W2037114191 hasConcept C2779631682 @default.
- W2037114191 hasConcept C50476208 @default.
- W2037114191 hasConcept C55493867 @default.
- W2037114191 hasConcept C86803240 @default.
- W2037114191 hasConceptScore W2037114191C104317684 @default.
- W2037114191 hasConceptScore W2037114191C143065580 @default.
- W2037114191 hasConceptScore W2037114191C153911025 @default.
- W2037114191 hasConceptScore W2037114191C159047783 @default.
- W2037114191 hasConceptScore W2037114191C181199279 @default.
- W2037114191 hasConceptScore W2037114191C185592680 @default.
- W2037114191 hasConceptScore W2037114191C202878990 @default.
- W2037114191 hasConceptScore W2037114191C2522874641 @default.
- W2037114191 hasConceptScore W2037114191C2779631682 @default.
- W2037114191 hasConceptScore W2037114191C50476208 @default.
- W2037114191 hasConceptScore W2037114191C55493867 @default.
- W2037114191 hasConceptScore W2037114191C86803240 @default.
- W2037114191 hasIssue "1-2" @default.
- W2037114191 hasLocation W20371141911 @default.
- W2037114191 hasLocation W20371141912 @default.
- W2037114191 hasOpenAccess W2037114191 @default.
- W2037114191 hasPrimaryLocation W20371141911 @default.
- W2037114191 hasRelatedWork W1487857142 @default.
- W2037114191 hasRelatedWork W1528827813 @default.
- W2037114191 hasRelatedWork W1837369178 @default.
- W2037114191 hasRelatedWork W1972338774 @default.
- W2037114191 hasRelatedWork W1992122389 @default.
- W2037114191 hasRelatedWork W2037114191 @default.
- W2037114191 hasRelatedWork W2065441927 @default.
- W2037114191 hasRelatedWork W2118087741 @default.
- W2037114191 hasRelatedWork W2126908420 @default.
- W2037114191 hasRelatedWork W343991036 @default.
- W2037114191 hasVolume "9" @default.
- W2037114191 isParatext "false" @default.
- W2037114191 isRetracted "false" @default.
- W2037114191 magId "2037114191" @default.
- W2037114191 workType "article" @default.