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• W2037116112 abstract "We have generated a gene trap insertion into the protein tyrosine phosphatase-BL (PTP-BL) locus, which produces a fusion of the N-terminal half of PTP-BL with β-galactosidase. During development, β-galactosidase activity was seen in all epithelial cells: strong staining was observed in the stomach and kidney epithelium, the ependymal layer of the central nervous system, and the surface ectoderm. Particularly prominent β-galactosidase activity was seen in the peripheral nervous system, which correlated with neurite outgrowth. In epithelial cells, staining was seen in the apical portion of the cells. In nerves, β-galactosidase activity was associated with growth cones as well as with Schwann cells. This suggests that the amino-terminal portion of PTP-BL contains sequences sufficient to target the fusion protein to specific subcellular compartments. In situ hybridization with a PTP-BL probe demonstrated that all tissues in which β-galactosidase activity was seen were genuine sites of expression of the PTP-BL gene, although differences in the stability of the PTP-BL protein and the PTP-BL-β-galactosidase fusion protein may exist. The distribution of β-galactosidase activity in the peripheral nervous system, together with the structure of the wild-type protein, suggests that this phosphatase may have a role in regulation of the cytoskeleton during the development of the peripheral nervous system. Dev. Dyn. 1998;212:250–257. © 1998 Wiley-Liss, Inc." @default.
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• W2037116112 date "1998-06-01" @default.
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• W2037116112 title "Distribution of a murine protein tyrosine phosphatase BL-β-galactosidase fusion protein suggests a role in neurite outgrowth" @default.
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• W2037116112 doi "https://doi.org/10.1002/(sici)1097-0177(199806)212:2<250::aid-aja9>3.0.co;2-g" @default.
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