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• W2037119234 abstract "Mild cognitive impairment (MCI) is regarded as a pre-clinical stage of dementia, particularly Alzheimer's disease (AD). Several MCI subtypes have been proposed based on distinct neuropsychological profiles, including amnestic MCI (aMCI), non-amnestic MCI (naMCI), and multi-domain MCI (mdMCI). Nevertheless, neuroimaging correlates of MCI remain controversial. We hypothesized that MCI brains can be differentiated from brains of normal controls (NC) based on integrity of limbic tracts (fornix and cingulum) and cortical glucose metabolism, and that MCI subtypes can be differentiated based on these markers of neuronal dysfunction. We studied 16 NC and 20 MCI patients (11 mdMCI; 4 aMCI; 5 naMCI) with diffusion tensor imaging (DTI) and FDG-PET. DTI images were acquired using these parameters: EPI, b = 1000 with 6 directions, 4 NEX, 3 mm^2 in-plane resolution with 3 mm slices, interpolated to voxel size of 1.5 mm^3. DTI tractography was used to map the fornix body, superior and descending cingulum, and posterior limb of internal capsule, and both fractional anisotropy (FA) and volume measurements were obtained for each structure. PET images were acquired following 10 mCi injection of FDG and compared to an age-matched normal database. Pons-normalized Z-scores were computed for posterior cingulate cortex (PCC), medial parietal cortex (MPC), parietal association cortex (PAC), temporal association cortex (TAC), and visual cortex using 3D-SSP technique. MCI cohort exhibited decreased fornix FA (p < 0.001) and descending cingulum volume (p = 0.001) relative to NC; neither FA nor volume of internal capsule (control) differed between groups. Fornix volume differed among MCI subtypes (p = 0.008), with aMCI (p < 0.05) and mdMCI (p < 0.01) exhibiting lower volumes than naMCI; however, fornix volume did not differ between aMCI and mdMCI. MCI cohort exhibited decreased PET Z-scores (all p < 0.001) in PCC, MPC, PAC, and TAC relative to the normal database; visual cortex (control) Z-scores did not differ between groups. MPC Z-scores differed among MCI subtypes (p = 0.006), with aMCI (p < 0.05) and mdMCI (p < 0.05) exhibiting lower Z-scores than naMCI; however, MPC Z-scores did not differ between aMCI and mdMCI. Fornix integrity and medial parietal cortical glucose metabolism, as measured by neuroimaging, can differentiate amnestic from non-amnestic subtypes of MCI." @default.
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• W2037119234 date "2010-07-01" @default.
• W2037119234 modified "2023-09-30" @default.
• W2037119234 title "IC-P-012: Subtypes of mild cognitive impairment differentiated based on limbic white matter integrity and cortical glucose metabolism: A pilot study using DTI and FDG-PET" @default.
• W2037119234 doi "https://doi.org/10.1016/j.jalz.2010.05.027" @default.
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