FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037127584> ?p ?o ?g. }

• W2037127584 endingPage "993" @default.
• W2037127584 startingPage "987" @default.
• W2037127584 abstract "Cells can respond to a sublethal oxidative stress by up-regulating their intracellular glutathione (GSH) pool. Such increased GSH concentration is likely to be protective against further oxidative challenge, and, in fact, pre-exposure to low levels of oxidants confers increased cellular resistance to subsequent greater oxidative stress. Previously, we have shown that pretreatment of rat lung epithelial L2 cells with sublethal concentrations of tert-butylhydroquinone (TBHQ) increases intracellular GSH concentration in a concentration-and time-dependent manner. This increase resulted from up-regulation of both γ-glutamyltranspeptidase (GGT) and γ-glutamylcysteine synthetase (GCS). Therefore, we investigated whether such increased GSH concentration protected these cells against a subtle loss in function caused by a subsequent challenge with sublethal concentrations of tert-butylhydroperoxide (tBOOH) (⩽200 μM), mimicking a physiological oxidative stress. Activation of L2 cell purinoreceptors with 100 μM ADP caused an elevation of intracellular Ca2+. This response was suppressed by a brief pre-exposure to tBOOH. The inhibition, however, was alleviated dramatically by a 16-hr pretreatment with 50 μM TBHQ. The same TBHQ pretreatment also protected the cells from ATP-depletion induced by tBOOH. l-Buthionine S,R-sulfoximine (BSO), an irreversible inhibitor of GCS, prevented the increase in intracellular GSH and also completely removed the protection by TBHQ in maintaining the ATP level. Thus, pre-exposure to a sublethal level of TBHQ results in protection of cell functions from hydroperoxide toxicity. This protection appears to depend on alteration of the intracellular GSH pool, the modulation of which constitutes an adaptive response to oxidative stress." @default.
• W2037127584 created "2016-06-24" @default.
• W2037127584 creator A5022255793 @default.
• W2037127584 creator A5031345172 @default.
• W2037127584 creator A5077204648 @default.
• W2037127584 date "1997-04-01" @default.
• W2037127584 modified "2023-10-16" @default.
• W2037127584 title "Adaptation to oxidative stress: Quinone-mediated protection of signaling in rat lung epithelial L2 cells" @default.
• W2037127584 cites W1530488971 @default.
• W2037127584 cites W1533084749 @default.
• W2037127584 cites W1533884457 @default.
• W2037127584 cites W1569322811 @default.
• W2037127584 cites W1580210576 @default.
• W2037127584 cites W1598595464 @default.
• W2037127584 cites W1602308712 @default.
• W2037127584 cites W1806242609 @default.
• W2037127584 cites W1971769351 @default.
• W2037127584 cites W1972477804 @default.
• W2037127584 cites W1972863039 @default.
• W2037127584 cites W1974175122 @default.
• W2037127584 cites W1975772473 @default.
• W2037127584 cites W1980249181 @default.
• W2037127584 cites W1991648320 @default.
• W2037127584 cites W2005166480 @default.
• W2037127584 cites W2009752174 @default.
• W2037127584 cites W2010785674 @default.
• W2037127584 cites W2013736309 @default.
• W2037127584 cites W2017786379 @default.
• W2037127584 cites W2035971243 @default.
• W2037127584 cites W2036118421 @default.
• W2037127584 cites W2036633822 @default.
• W2037127584 cites W2042741874 @default.
• W2037127584 cites W2048040489 @default.
• W2037127584 cites W2069123268 @default.
• W2037127584 cites W2078031827 @default.
• W2037127584 cites W2079506356 @default.
• W2037127584 cites W2086815776 @default.
• W2037127584 cites W2101233343 @default.
• W2037127584 cites W2113807212 @default.
• W2037127584 cites W2120197534 @default.
• W2037127584 cites W2121380625 @default.
• W2037127584 cites W2123085934 @default.
• W2037127584 cites W2135387911 @default.
• W2037127584 cites W2141260882 @default.
• W2037127584 cites W2192588842 @default.
• W2037127584 cites W2254628979 @default.
• W2037127584 cites W2420714045 @default.
• W2037127584 cites W4232534952 @default.
• W2037127584 cites W7222078 @default.
• W2037127584 doi "https://doi.org/10.1016/s0006-2952(96)00867-2" @default.
• W2037127584 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9174112" @default.
• W2037127584 hasPublicationYear "1997" @default.
• W2037127584 type Work @default.
• W2037127584 sameAs 2037127584 @default.
• W2037127584 citedByCount "53" @default.
• W2037127584 countsByYear W20371275842012 @default.
• W2037127584 countsByYear W20371275842013 @default.
• W2037127584 countsByYear W20371275842014 @default.
• W2037127584 countsByYear W20371275842015 @default.
• W2037127584 countsByYear W20371275842016 @default.
• W2037127584 countsByYear W20371275842017 @default.
• W2037127584 countsByYear W20371275842019 @default.
• W2037127584 countsByYear W20371275842020 @default.
• W2037127584 countsByYear W20371275842023 @default.
• W2037127584 crossrefType "journal-article" @default.
• W2037127584 hasAuthorship W2037127584A5022255793 @default.
• W2037127584 hasAuthorship W2037127584A5031345172 @default.
• W2037127584 hasAuthorship W2037127584A5077204648 @default.
• W2037127584 hasConcept C181199279 @default.
• W2037127584 hasConcept C185592680 @default.
• W2037127584 hasConcept C2776151105 @default.
• W2037127584 hasConcept C2777476445 @default.
• W2037127584 hasConcept C538909803 @default.
• W2037127584 hasConcept C55493867 @default.
• W2037127584 hasConcept C57600042 @default.
• W2037127584 hasConcept C79879829 @default.
• W2037127584 hasConcept C86803240 @default.
• W2037127584 hasConcept C98274493 @default.
• W2037127584 hasConceptScore W2037127584C181199279 @default.
• W2037127584 hasConceptScore W2037127584C185592680 @default.
• W2037127584 hasConceptScore W2037127584C2776151105 @default.
• W2037127584 hasConceptScore W2037127584C2777476445 @default.
• W2037127584 hasConceptScore W2037127584C538909803 @default.
• W2037127584 hasConceptScore W2037127584C55493867 @default.
• W2037127584 hasConceptScore W2037127584C57600042 @default.
• W2037127584 hasConceptScore W2037127584C79879829 @default.
• W2037127584 hasConceptScore W2037127584C86803240 @default.
• W2037127584 hasConceptScore W2037127584C98274493 @default.
• W2037127584 hasFunder F4320332161 @default.
• W2037127584 hasIssue "7" @default.
• W2037127584 hasLocation W20371275841 @default.
• W2037127584 hasLocation W20371275842 @default.
• W2037127584 hasOpenAccess W2037127584 @default.
• W2037127584 hasPrimaryLocation W20371275841 @default.
• W2037127584 hasRelatedWork W1549498308 @default.
• W2037127584 hasRelatedWork W1593739904 @default.
• W2037127584 hasRelatedWork W2000917288 @default.
• W2037127584 hasRelatedWork W2001778733 @default.

• next