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- W2037133065 abstract "Plasma corticosteroid concentrations were significantly elevated 15 min after intraperitoneal (i.p.) injection of 90 μmoles of diquat/kg body wt (ld50 dose) into phenobarbitone anaesthetised rats. Similar effects were noted after subcutaneous dosing but after oral administration there was a delay of approximately 1 hr before significantly elevated concentrations were observed. The magnitude of the increase after i.p. administration of diquat was dose-related up to 26 μmoles/kg body wt, as was the duration of the response. The increase in plasma corticosteroid concentration in diquat-treated rats could be prevented by pretreating animals with dexamethasone which also reduced adrenocorticotrophic hormone (ACTH) concentration in these animals. Experiments in vivo and in vitro indicated that diquat did not increase the steroidogenic response of adrenals to ACTH. It is concluded that the increased adrenal steroid synthesis observed at early times after diquat administration is caused by release of ACTH from the pituitary." @default.
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- W2037133065 date "1976-11-01" @default.
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- W2037133065 title "Early effects of diquat on plasma corticosteroid concentrations in rats" @default.
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- W2037133065 doi "https://doi.org/10.1016/0006-2952(76)90449-4" @default.
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