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• W2037133346 startingPage "6892" @default.
• W2037133346 abstract "Campylobacter and Helicobacter species express a 6-amino-6-deoxyfutalosine N-ribosylhydrolase (HpMTAN) proposed to function in menaquinone synthesis. BuT-DADMe-ImmA is a 36 pM transition state analogue of HpMTAN, and the crystal structure of the enzyme–inhibitor complex reveals the mechanism of inhibition. BuT-DADMe-ImmA has a MIC90 value of <8 ng/mL for Helicobacter pylori growth but does not cause growth arrest in other common clinical pathogens, thus demonstrating potential as an H. pylori-specific antibiotic." @default.
• W2037133346 created "2016-06-24" @default.
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• W2037133346 date "2012-08-22" @default.
• W2037133346 modified "2023-10-16" @default.
• W2037133346 title "A Picomolar Transition State Analogue Inhibitor of MTAN as a Specific Antibiotic for <i>Helicobacter pylori</i>" @default.
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• W2037133346 doi "https://doi.org/10.1021/bi3009664" @default.
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