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• W2037135514 abstract "High-frequency stimulation (HFS) of the subthalamic nucleus (STN) alleviates the cardinal symptoms of Parkinson's disease, but the mechanisms underlying these clinical results remain to be clarified. The HFS of STN is associated with the release of dopamine (DA) in the striatum. This study examines possible mechanisms by which HFS-STN release DA. The experiments were performed in rats anesthetized with urethane. The STN was stimulated by electrical HF and chemical microinjections of an antagonist and an agonist of GABA(A) receptors, the bicuculline, and the muscimol, respectively. The extracellular striatal DA-DOPAC (3-4-dihydroxyphenilacetic acid) content was collected by means of intracerebral microdialysis cannula and analyzed with HPLC with an electrochemical detector. The HFS of STN and microinjection of bicuculline intrasubthalamic produced a significant increase of extracellular striatal DA, whereas DOPAC levels were unchanged. The microinjection of muscimol depresses spontaneous release of DA, without changes in DOPAC. The kainic acid lesion of the globus pallidus (GP) and the substantia nigra pars reticulata (SNr), ipsilateral to dialyzed striatum, did not modify the release of DA-DOPAC. These data provide evidence that the STN has a tonic action on the substantia nigra pars compacta (SNc), and the release of striatal DA by HFS-STN may be due to activation of the STN acting directly on SNc neurons." @default.
• W2037135514 created "2016-06-24" @default.
• W2037135514 creator A5007335457 @default.
• W2037135514 creator A5026522130 @default.
• W2037135514 creator A5042923149 @default.
• W2037135514 creator A5072481991 @default.
• W2037135514 creator A5072941524 @default.
• W2037135514 date "2010-04-23" @default.
• W2037135514 modified "2023-09-27" @default.
• W2037135514 title "Effect of electrical and chemical stimulation of the subthalamic nucleus on the release of striatal dopamine" @default.
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• W2037135514 doi "https://doi.org/10.1002/syn.20809" @default.
• W2037135514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20939061" @default.
• W2037135514 hasPublicationYear "2010" @default.
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