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- W2037135590 abstract "A new design of antioxidant, consisting of manganese (Mn) porphyrin and signal peptide for mitochondrial targeting, is reported. The resulting Mn-porphyrin-oligopeptide conjugate exhibited significant superoxide dismutase (SOD) activity and decomposed peroxynitrite (ONOO-). The new antioxidant caused the swelling of isolated mitochondria. By using the pH-sensitive drug carrier for intracellular delivery, furthermore, the new conjugate recovered the viability of lipopolysaccharide (LPS)-stimulated macrophage RAW 264.7 cells. These results suggest that the Mn-porphyrin modified with signal peptide for mitochondrial targeting is promising for a new class of antioxidants." @default.
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- W2037135590 date "2006-06-09" @default.
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- W2037135590 title "Design of Manganese Porphyrin Modified with Mitochondrial Signal Peptide for a New Antioxidant" @default.
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- W2037135590 doi "https://doi.org/10.1021/mp0500667" @default.
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