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• W2037142401 abstract "BACKGROUND: Septic transfusion reactions to apheresis platelets (PLTs) continue to occur despite preventive measures. This study evaluated the effect of two operational changes designed to reduce bacterial risk: 1) introducing inlet‐line sample diversion on two‐arm procedures and 2) increasing the sample volume cultured from 4 to 8 mL from all donations. STUDY DESIGN AND METHODS: Aerobic culture results and septic transfusion reactions reported between December 1, 2006, and July 31, 2008 (Period 2), were compared to March 1, 2004, to May 31, 2006 (Period 1). RESULTS: During Period 2, a total of 781,936 apheresis PLT collections were cultured, of which 130 donations (1:6015) were confirmed positive and 9 (1:86,882) had negative culture results but were associated with 11 septic reactions. Confirmed‐positive cultures from two‐arm procedures decreased (27.2 to 14.7 per 10 5 collections; odds ratio [OR], 0.54; 95% confidence interval [CI], 0.41‐0.70) in Period 2, owing to a lower rate of skin flora contamination. Detection of contamination of one‐arm collections significantly increased by 54% in Period 2 (13.7 vs. 21.1 per 10 5 collections; OR, 1.54; 95% CI, 1.05‐2.27). Fewer septic transfusion reactions occurred in Period 2, but the difference did not reach significance (1.7 vs. 1.2 per 10 5 donations; OR, 0.68; 95% CI, 0.30‐1.53). CONCLUSION: Inlet‐line diversion decreased bacterial contamination during two‐arm collections by more than 46%. Concurrently, doubling the sample volume was associated with a 54% relative increase in culture sensitivity. These interventions act cooperatively to decrease bacterial risk." @default.
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• W2037142401 date "2009-07-30" @default.
• W2037142401 modified "2023-10-16" @default.
• W2037142401 title "Limiting and detecting bacterial contamination of apheresis platelets: inlet-line diversion and increased culture volume improve component safety" @default.
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• W2037142401 doi "https://doi.org/10.1111/j.1537-2995.2009.02192.x" @default.
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