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• W2037143450 abstract "Due to the avascular nature of articular cartilage, solute transport through its extracellular matrix is critical for the maintenance and the functioning of the tissue. What is more, diffusion of macromolecules may be affected by the microstructure of the extracellular matrix in both undeformed and deformed cartilage and experiments demonstrate diffusion anisotropy in the case of large solute. However, these phenomena have not received sufficient theoretical attention to date. We hypothesize here that the diffusion anisotropy of macromolecules is brought about by the particular microstructure of the cartilage network. Based on this hypothesis, we then propose a mathematical model that correlates the diffusion coefficient tensor with the structural orientation tensor of the network. This model is shown to be successful in describing anisotropic diffusion of macromolecules in undeformed tissue and is capable of clarifying the effects of network reorientation as the tissue deforms under mechanical load. Additionally, our model explains the anomaly that at large strain, in a cylindrical plug under unconfined compression, solute diffusion in the radial direction increases with strain. Our results indicate that in cartilage the degree of diffusion anisotropy is site specific, but depends also on the size of the diffusing molecule. Mechanical loading initiates and/or further exacerbates this anisotropy. At small deformation, solute diffusion is near isotropic in a tissue that is isotropic in its unstressed state, becoming anisotropic as loading progresses. Mechanical loading leads to an attenuation of solute diffusion in all directions when deformation is small. However, loading, if it is high enough, enhances solute transport in the direction perpendicular to the load line, instead of inhibiting it." @default.
• W2037143450 created "2016-06-24" @default.
• W2037143450 creator A5021019207 @default.
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• W2037143450 date "2008-01-01" @default.
• W2037143450 modified "2023-09-27" @default.
• W2037143450 title "Transport of neutral solute in articular cartilage: Effect of microstructure anisotropy" @default.
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• W2037143450 doi "https://doi.org/10.1016/j.jbiomech.2007.08.005" @default.
• W2037143450 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2265594" @default.
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