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• W2037152904 abstract "We investigated the neuroprotective property of analogs of dextromethorphan (DM) in lipopolysaccharide (LPS) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) models to identify neuroprotective drugs for Parkinson's disease (PD). In vivo studies showed that daily injections with DM analogs protected dopamine (DA) neurons in substantia nigra pars compacta and restored DA levels in striatum using two different models for PD. Of the five analogs studied, 3-hydroxymorphinan (3-HM), a metabolite of DM, was the most potent, and restored DA neuronal loss and DA depletion up to 90% of the controls. Behavioral studies showed an excellent correlation between potency for preventing toxin-induced decrease in motor activities and neuroprotective effects among the DM analogs studied, of which 3-HM was the most potent in attenuating behavioral damage. In vitro studies revealed two glia-dependent mechanisms for the neuroprotection by 3-HM. First, astroglia mediated the 3-HM-induced neurotrophic effect by increasing the gene expression of neurotrophic factors, which was associated with the increased acetylation of histone H3. Second, microglia participated in 3-HM-mediated neuroprotection by reducing MPTP-elicited reactive microgliosis as evidenced by the decreased production of reactive oxygen species. In summary, we show the potent neuroprotection by 3-HM in LPS and MPTP PD models investigated. With its high efficacy and low toxicity, 3-HM may be a novel therapy for PD." @default.
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• W2037152904 date "2006-12-01" @default.
• W2037152904 modified "2023-10-18" @default.
• W2037152904 title "3‐Hydroxymorphinan, a metabolite of dextromethorphan, protects nigrostriatal pathway against MPTP‐elicited damage both <i>in vivo</i> and <i>in vitro</i>" @default.
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• W2037152904 cites W1554054932 @default.
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• W2037152904 cites W1587360940 @default.
• W2037152904 cites W1606843899 @default.
• W2037152904 cites W1820697593 @default.
• W2037152904 cites W1965433071 @default.
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• W2037152904 cites W1968666033 @default.
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• W2037152904 cites W2004555438 @default.
• W2037152904 cites W2011676774 @default.
• W2037152904 cites W2015629481 @default.
• W2037152904 cites W2021882446 @default.
• W2037152904 cites W2022345547 @default.
• W2037152904 cites W2024955746 @default.
• W2037152904 cites W2027021803 @default.
• W2037152904 cites W2032247291 @default.
• W2037152904 cites W2032611317 @default.
• W2037152904 cites W2032895185 @default.
• W2037152904 cites W2039190334 @default.
• W2037152904 cites W2054300604 @default.
• W2037152904 cites W2054789114 @default.
• W2037152904 cites W2056196016 @default.
• W2037152904 cites W2064689672 @default.
• W2037152904 cites W2068287578 @default.
• W2037152904 cites W2068303011 @default.
• W2037152904 cites W2070662665 @default.
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• W2037152904 cites W2117691193 @default.
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• W2037152904 cites W2127233792 @default.
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• W2037152904 cites W2147313422 @default.
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• W2037152904 doi "https://doi.org/10.1096/fj.06-6006com" @default.
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