FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037156588> ?p ?o ?g. }

• W2037156588 abstract "Gene therapy is a treatment for inborn and acquired diseases, although the development of safe and effective gene delivery system is a great challenge to make a gene therapy a success. Viral vectors have been used in a majority of clinics because of their high transfection efficiency in vitro and in vivo. However, their use has been limited because of several drawbacks, such as induction of immune response, recombination of wild-type viruses, limitation in the size of inserted gene, and difficulty in large-scale production. Nonviral vectors have been widely proposed safe alternatives to viral vectors because they have low immunogenicity, flexibility in the size of gene to be delivered, cell targetibility, and easy scalability of production, although they have low transfection efficiency compared to viral vectors. Among nonviral vectors, polyethylenimine (PEI) has been widely used as a standard gene carriers due to its high pH-buffering capacity for endosomal escape although high-molecular-weight PEI is too toxic owing to non-degradability. Recently, many types of degradable PEI have been studied due to high transfection efficiency with lower cytotoxicity. This review explains recent progress on the development of degradable PEIs as nonviral vectors. The present paper summarizes the transfection efficiency of DNA or silencing efficiency of small interfering RNA (siRNA) based on the kinds of degradable linkage between low PEI and crosslinkers. Degradable linkages, such as ester, disulfide, imines, carbamate, amide and ketal in the degradable PEIs are covered." @default.
• W2037156588 created "2016-06-24" @default.
• W2037156588 creator A5005587787 @default.
• W2037156588 creator A5006720579 @default.
• W2037156588 creator A5010758104 @default.
• W2037156588 creator A5028658999 @default.
• W2037156588 creator A5042739869 @default.
• W2037156588 creator A5049245025 @default.
• W2037156588 creator A5075453290 @default.
• W2037156588 date "2012-03-01" @default.
• W2037156588 modified "2023-09-23" @default.
• W2037156588 title "DEGRADABLE POLYETHYLENIMINE DERIVATIVES AS GENE CARRIERS" @default.
• W2037156588 cites W1580847663 @default.
• W2037156588 cites W1606853210 @default.
• W2037156588 cites W1891967301 @default.
• W2037156588 cites W1963973175 @default.
• W2037156588 cites W1975600099 @default.
• W2037156588 cites W1979583277 @default.
• W2037156588 cites W1980435799 @default.
• W2037156588 cites W1984568212 @default.
• W2037156588 cites W1988140847 @default.
• W2037156588 cites W1989564585 @default.
• W2037156588 cites W1990369593 @default.
• W2037156588 cites W1993553186 @default.
• W2037156588 cites W1998084471 @default.
• W2037156588 cites W1998088479 @default.
• W2037156588 cites W1998118881 @default.
• W2037156588 cites W1999517163 @default.
• W2037156588 cites W2001218002 @default.
• W2037156588 cites W2005064010 @default.
• W2037156588 cites W2006604904 @default.
• W2037156588 cites W2008026046 @default.
• W2037156588 cites W2010655741 @default.
• W2037156588 cites W2011411949 @default.
• W2037156588 cites W2012768324 @default.
• W2037156588 cites W2019051726 @default.
• W2037156588 cites W2025028210 @default.
• W2037156588 cites W2028831330 @default.
• W2037156588 cites W2029787326 @default.
• W2037156588 cites W2030556927 @default.
• W2037156588 cites W2032307190 @default.
• W2037156588 cites W2033063864 @default.
• W2037156588 cites W2034474981 @default.
• W2037156588 cites W2041874034 @default.
• W2037156588 cites W2042786578 @default.
• W2037156588 cites W2043977379 @default.
• W2037156588 cites W2047649932 @default.
• W2037156588 cites W2048881858 @default.
• W2037156588 cites W2049768355 @default.
• W2037156588 cites W2052073531 @default.
• W2037156588 cites W2059262359 @default.
• W2037156588 cites W2065458712 @default.
• W2037156588 cites W2068435758 @default.
• W2037156588 cites W2068769475 @default.
• W2037156588 cites W2071033327 @default.
• W2037156588 cites W2073151449 @default.
• W2037156588 cites W2077760797 @default.
• W2037156588 cites W2078273989 @default.
• W2037156588 cites W2087497808 @default.
• W2037156588 cites W2094101506 @default.
• W2037156588 cites W2094641772 @default.
• W2037156588 cites W2128314443 @default.
• W2037156588 cites W2151091220 @default.
• W2037156588 cites W4232534952 @default.
• W2037156588 doi "https://doi.org/10.1142/s1793984411000335" @default.
• W2037156588 hasPublicationYear "2012" @default.
• W2037156588 type Work @default.
• W2037156588 sameAs 2037156588 @default.
• W2037156588 citedByCount "6" @default.
• W2037156588 countsByYear W20371565882012 @default.
• W2037156588 countsByYear W20371565882014 @default.
• W2037156588 countsByYear W20371565882015 @default.
• W2037156588 countsByYear W20371565882016 @default.
• W2037156588 crossrefType "journal-article" @default.
• W2037156588 hasAuthorship W2037156588A5005587787 @default.
• W2037156588 hasAuthorship W2037156588A5006720579 @default.
• W2037156588 hasAuthorship W2037156588A5010758104 @default.
• W2037156588 hasAuthorship W2037156588A5028658999 @default.
• W2037156588 hasAuthorship W2037156588A5042739869 @default.
• W2037156588 hasAuthorship W2037156588A5049245025 @default.
• W2037156588 hasAuthorship W2037156588A5075453290 @default.
• W2037156588 hasConcept C104317684 @default.
• W2037156588 hasConcept C111599444 @default.
• W2037156588 hasConcept C119056186 @default.
• W2037156588 hasConcept C135983454 @default.
• W2037156588 hasConcept C166703698 @default.
• W2037156588 hasConcept C185592680 @default.
• W2037156588 hasConcept C22615655 @default.
• W2037156588 hasConcept C2775925850 @default.
• W2037156588 hasConcept C2780868878 @default.
• W2037156588 hasConcept C32470452 @default.
• W2037156588 hasConcept C40767141 @default.
• W2037156588 hasConcept C54009773 @default.
• W2037156588 hasConcept C54355233 @default.
• W2037156588 hasConcept C67705224 @default.
• W2037156588 hasConcept C70721500 @default.
• W2037156588 hasConcept C86803240 @default.
• W2037156588 hasConcept C8891405 @default.
• W2037156588 hasConcept C92087593 @default.
• W2037156588 hasConceptScore W2037156588C104317684 @default.

• next