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- W2037156957 abstract "Enkephalin analog with thiol group at C-terminus, [D-Ala2, Leu(CH2SH)5]enkephalin, was synthesized as possible probe for the essential thiol group in opiate receptors. In order to protect the free SH group of leucinthiol, oxidized Boc-L-leucinthiol dimer was prepared from L-leucinol (2-amino-4-methyl-1-pentanol) to elongate the enkephalin sequence. SH-Containing monomeric enkephalin analog was obtained from dimer by treatment with zinc in 50% AcOH, and it exhibited a high affinity for mu opiate receptors." @default.
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- W2037156957 date "1987-05-05" @default.
- W2037156957 modified "2023-10-16" @default.
- W2037156957 title "Synthesis of Enkephalin Analog with Leucinthiol at<i>C</i>-Terminus as Probe for Thiol Group in Opiate Receptors" @default.
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- W2037156957 doi "https://doi.org/10.1246/cl.1987.997" @default.
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