Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037157460> ?p ?o ?g. }
- W2037157460 endingPage "4156" @default.
- W2037157460 startingPage "4137" @default.
- W2037157460 abstract "A novel series of erythromycin derivatives has been discovered with potent activity against key respiratory pathogens, including those resistant to erythromycin. These compounds are characterized by having an aryl group tethered to the C-6 position of the erythronolide skeleton. Extensive structural modification of the C-6 moiety led to the discovery of several promising compounds with potent activity against both mef- and erm-mediated resistant Streptoccoccus pneumoniae. Preliminary mechanistic studies indicated that the new macrolides are potent protein synthesis inhibitors, which interact with methylated ribosomes isolated from resistant organisms. In experimental animal models, these compounds exhibited excellent in vivo efficacy and balanced pharmacokinetic profiles." @default.
- W2037157460 created "2016-06-24" @default.
- W2037157460 creator A5000329049 @default.
- W2037157460 creator A5006715126 @default.
- W2037157460 creator A5019694615 @default.
- W2037157460 creator A5021646889 @default.
- W2037157460 creator A5021758461 @default.
- W2037157460 creator A5022513094 @default.
- W2037157460 creator A5033620667 @default.
- W2037157460 creator A5042232889 @default.
- W2037157460 creator A5047005150 @default.
- W2037157460 creator A5050371244 @default.
- W2037157460 creator A5052370468 @default.
- W2037157460 creator A5053533157 @default.
- W2037157460 creator A5054286201 @default.
- W2037157460 creator A5055100036 @default.
- W2037157460 creator A5059266311 @default.
- W2037157460 creator A5059488443 @default.
- W2037157460 creator A5060966004 @default.
- W2037157460 creator A5073231197 @default.
- W2037157460 creator A5076677575 @default.
- W2037157460 creator A5077797964 @default.
- W2037157460 creator A5083434196 @default.
- W2037157460 creator A5086905802 @default.
- W2037157460 creator A5087511213 @default.
- W2037157460 creator A5089200254 @default.
- W2037157460 date "2001-10-18" @default.
- W2037157460 modified "2023-10-03" @default.
- W2037157460 title "Novel Erythromycin Derivatives with Aryl Groups Tethered to the C-6 Position Are Potent Protein Synthesis Inhibitors and Active against Multidrug-Resistant Respiratory Pathogens" @default.
- W2037157460 cites W1554612821 @default.
- W2037157460 cites W1970211626 @default.
- W2037157460 cites W1970561727 @default.
- W2037157460 cites W1972091733 @default.
- W2037157460 cites W1987920630 @default.
- W2037157460 cites W1989823425 @default.
- W2037157460 cites W1990911521 @default.
- W2037157460 cites W1998019505 @default.
- W2037157460 cites W2004392188 @default.
- W2037157460 cites W2006595179 @default.
- W2037157460 cites W2006684413 @default.
- W2037157460 cites W2015031068 @default.
- W2037157460 cites W2020845510 @default.
- W2037157460 cites W2026092337 @default.
- W2037157460 cites W2032393049 @default.
- W2037157460 cites W2039026588 @default.
- W2037157460 cites W2039326290 @default.
- W2037157460 cites W2043158848 @default.
- W2037157460 cites W2047275679 @default.
- W2037157460 cites W2050532926 @default.
- W2037157460 cites W2052074963 @default.
- W2037157460 cites W2052968490 @default.
- W2037157460 cites W2069966411 @default.
- W2037157460 cites W2077657189 @default.
- W2037157460 cites W2084388805 @default.
- W2037157460 cites W2097654784 @default.
- W2037157460 cites W2100843620 @default.
- W2037157460 cites W2101731769 @default.
- W2037157460 cites W2104500040 @default.
- W2037157460 cites W2120987483 @default.
- W2037157460 cites W2145517870 @default.
- W2037157460 cites W2150850263 @default.
- W2037157460 cites W2158453986 @default.
- W2037157460 cites W2158583961 @default.
- W2037157460 cites W4231112548 @default.
- W2037157460 cites W4233619092 @default.
- W2037157460 doi "https://doi.org/10.1021/jm0102349" @default.
- W2037157460 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11708916" @default.
- W2037157460 hasPublicationYear "2001" @default.
- W2037157460 type Work @default.
- W2037157460 sameAs 2037157460 @default.
- W2037157460 citedByCount "108" @default.
- W2037157460 countsByYear W20371574602012 @default.
- W2037157460 countsByYear W20371574602013 @default.
- W2037157460 countsByYear W20371574602014 @default.
- W2037157460 countsByYear W20371574602015 @default.
- W2037157460 countsByYear W20371574602016 @default.
- W2037157460 countsByYear W20371574602017 @default.
- W2037157460 countsByYear W20371574602018 @default.
- W2037157460 countsByYear W20371574602019 @default.
- W2037157460 countsByYear W20371574602020 @default.
- W2037157460 countsByYear W20371574602021 @default.
- W2037157460 countsByYear W20371574602023 @default.
- W2037157460 crossrefType "journal-article" @default.
- W2037157460 hasAuthorship W2037157460A5000329049 @default.
- W2037157460 hasAuthorship W2037157460A5006715126 @default.
- W2037157460 hasAuthorship W2037157460A5019694615 @default.
- W2037157460 hasAuthorship W2037157460A5021646889 @default.
- W2037157460 hasAuthorship W2037157460A5021758461 @default.
- W2037157460 hasAuthorship W2037157460A5022513094 @default.
- W2037157460 hasAuthorship W2037157460A5033620667 @default.
- W2037157460 hasAuthorship W2037157460A5042232889 @default.
- W2037157460 hasAuthorship W2037157460A5047005150 @default.
- W2037157460 hasAuthorship W2037157460A5050371244 @default.
- W2037157460 hasAuthorship W2037157460A5052370468 @default.
- W2037157460 hasAuthorship W2037157460A5053533157 @default.
- W2037157460 hasAuthorship W2037157460A5054286201 @default.
- W2037157460 hasAuthorship W2037157460A5055100036 @default.
- W2037157460 hasAuthorship W2037157460A5059266311 @default.