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• W2037169679 abstract "A new highly selective inhibitor of acetylcholinesterase (AChE) was discovered by high-throughput screening. Compound 1 was synthesized from a natural product, the N-3-isobutyrylcycloxobuxidine-F 2. A new extraction protocol of this compound is described. The hemisynthesis and optimization of 1 are reported. The analogs of 1 were tested in vitro for the inhibition of both cholinesterases (AChE and BuChE). These compounds selectively inhibited AChE. Extensive molecular docking studies were performed with 2 and AChE employing Discover Biosym software to rationalize the binding interaction. The results suggested that ligand 2 binds simultaneously to both catalytic and peripheral sites of AChE." @default.
• W2037169679 created "2016-06-24" @default.
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• W2037169679 date "2007-09-29" @default.
• W2037169679 modified "2023-09-30" @default.
• W2037169679 title "New Potent Acetylcholinesterase Inhibitors in the Tetracyclic Triterpene Series" @default.
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• W2037169679 doi "https://doi.org/10.1021/jm070536w" @default.
• W2037169679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17902635" @default.
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