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• W2037171056 startingPage "53" @default.
• W2037171056 abstract "Immunohistochemical and histopathological studies were conducted in two marine teleosts, Atlantic cod (Gadus morhua) and European flounder (Platichthys flesus), caged for three months on contaminated sediments in a Norwegian fjord. Cellular localization of CYP1A was analyzed immunohistochemically in liver, intestine, heart, gill and kidney, as part of an extensive study that included a number of chemical and biological measurements. Both species exhibited marked CYP1A induction when caged at contaminated sites. CYP1A induction was observed in liver as well as in several extrahepatic organs, and with increased expression at the more contaminated sites. Staining was particularly strong in vascular endothelium. Induction responses were also observed in epithelial cells, including hepatocytes, biliary epithelial cells, mucosal epithelial cells in the intestine, and renal tubular epithelial cells. Histopathological examination of the liver did not reveal major cellular abnormalities. The immunohistochemical data indicate a strong relationship between CYP1A induction and exposure to sediment-associated industrial contaminants (polycyclic aromatic hydrocarbons). Interesting species differences in localization of CYP1A expression in various cell types in cod and flounder were demonstrated immunohistochemically." @default.
• W2037171056 created "2016-06-24" @default.
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• W2037171056 creator A5059289971 @default.
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• W2037171056 date "1996-11-01" @default.
• W2037171056 modified "2023-10-10" @default.
• W2037171056 title "Cellular localization of cytochrome P450 (CYP1A) induction and histology in Atlantic cod (Gadus morhua L.) and European flounder (Platichthys flesus) after environmental exposure to contaminants by caging in Sørfjorden, Norway" @default.
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• W2037171056 doi "https://doi.org/10.1016/s0166-445x(96)00797-7" @default.
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