Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037172853> ?p ?o ?g. }
- W2037172853 endingPage "222" @default.
- W2037172853 startingPage "212" @default.
- W2037172853 abstract "The generalist Salmonella enterica serovar Typhimurium causes disease in many animal species, but the closely related host-specific serovar Typhi only causes disease in humans. Typhi and Typhimurium share major virulence loci; hence it is not known exactly why Typhi does not cause disease in mice. We tested the hypothesis that macrophages contribute to Salmonella host-specificity in mice. No significant difference in survival of the two serovars was observed in vitro in mouse macrophage cell lines and primary murine peritoneal and bone marrow-derived macrophages after 24 h. In contrast, differential survival was observed following infection in vivo. When BALB/c mice were infected intraperitoneally (i.p.), both Typhi and Typhimurium induced neutrophil influx into the peritoneum and macrophages were the major cell type containing internalized bacteria at 0.5 and 4 h post-infection for both serovars. The number of Typhimurium in macrophages remained high at 4 h post-infection, but the number of Typhi in macrophages decreased substantially within 4 h after i.p. infection. These results indicate that macrophages are able to distinguish Typhi from Typhimurium when infected in vivo but no significant differences were observed after 24 h in vitro, suggesting that the differential killing of the two serovars by macrophages requires additional factors within the host." @default.
- W2037172853 created "2016-06-24" @default.
- W2037172853 creator A5006805410 @default.
- W2037172853 creator A5016702851 @default.
- W2037172853 creator A5055383437 @default.
- W2037172853 date "2009-10-01" @default.
- W2037172853 modified "2023-10-18" @default.
- W2037172853 title "Macrophages influence Salmonella host-specificity in vivo" @default.
- W2037172853 cites W1504182415 @default.
- W2037172853 cites W1517803157 @default.
- W2037172853 cites W1602437032 @default.
- W2037172853 cites W1799115436 @default.
- W2037172853 cites W1900142353 @default.
- W2037172853 cites W1931304351 @default.
- W2037172853 cites W1969047037 @default.
- W2037172853 cites W1971681859 @default.
- W2037172853 cites W1971708565 @default.
- W2037172853 cites W1974044888 @default.
- W2037172853 cites W1989511723 @default.
- W2037172853 cites W1989599765 @default.
- W2037172853 cites W1992144107 @default.
- W2037172853 cites W1992697273 @default.
- W2037172853 cites W1996770717 @default.
- W2037172853 cites W1999116680 @default.
- W2037172853 cites W2000853564 @default.
- W2037172853 cites W2006456690 @default.
- W2037172853 cites W2007462124 @default.
- W2037172853 cites W2009559365 @default.
- W2037172853 cites W2012437302 @default.
- W2037172853 cites W2013015490 @default.
- W2037172853 cites W2017090013 @default.
- W2037172853 cites W2018794044 @default.
- W2037172853 cites W2021635331 @default.
- W2037172853 cites W2026571365 @default.
- W2037172853 cites W2028982649 @default.
- W2037172853 cites W2032078625 @default.
- W2037172853 cites W2044571296 @default.
- W2037172853 cites W2052530009 @default.
- W2037172853 cites W2055142008 @default.
- W2037172853 cites W2056646841 @default.
- W2037172853 cites W2063576137 @default.
- W2037172853 cites W2063669058 @default.
- W2037172853 cites W2064567333 @default.
- W2037172853 cites W2066271947 @default.
- W2037172853 cites W2075628450 @default.
- W2037172853 cites W2075756658 @default.
- W2037172853 cites W2077702220 @default.
- W2037172853 cites W2080404458 @default.
- W2037172853 cites W2085603966 @default.
- W2037172853 cites W2093427530 @default.
- W2037172853 cites W2095115220 @default.
- W2037172853 cites W2097866765 @default.
- W2037172853 cites W2111092197 @default.
- W2037172853 cites W2120622159 @default.
- W2037172853 cites W2123972983 @default.
- W2037172853 cites W2124021158 @default.
- W2037172853 cites W2125510483 @default.
- W2037172853 cites W2127259414 @default.
- W2037172853 cites W2128318154 @default.
- W2037172853 cites W2131511868 @default.
- W2037172853 cites W2143286868 @default.
- W2037172853 cites W2151172094 @default.
- W2037172853 cites W2151350483 @default.
- W2037172853 cites W2156818006 @default.
- W2037172853 cites W2162991963 @default.
- W2037172853 cites W2164801366 @default.
- W2037172853 cites W83102131 @default.
- W2037172853 doi "https://doi.org/10.1016/j.micpath.2009.07.004" @default.
- W2037172853 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19660538" @default.
- W2037172853 hasPublicationYear "2009" @default.
- W2037172853 type Work @default.
- W2037172853 sameAs 2037172853 @default.
- W2037172853 citedByCount "20" @default.
- W2037172853 countsByYear W20371728532013 @default.
- W2037172853 countsByYear W20371728532014 @default.
- W2037172853 countsByYear W20371728532015 @default.
- W2037172853 countsByYear W20371728532017 @default.
- W2037172853 countsByYear W20371728532019 @default.
- W2037172853 countsByYear W20371728532020 @default.
- W2037172853 countsByYear W20371728532021 @default.
- W2037172853 countsByYear W20371728532022 @default.
- W2037172853 countsByYear W20371728532023 @default.
- W2037172853 crossrefType "journal-article" @default.
- W2037172853 hasAuthorship W2037172853A5006805410 @default.
- W2037172853 hasAuthorship W2037172853A5016702851 @default.
- W2037172853 hasAuthorship W2037172853A5055383437 @default.
- W2037172853 hasConcept C10389963 @default.
- W2037172853 hasConcept C104317684 @default.
- W2037172853 hasConcept C150903083 @default.
- W2037172853 hasConcept C202751555 @default.
- W2037172853 hasConcept C207001950 @default.
- W2037172853 hasConcept C2779244956 @default.
- W2037172853 hasConcept C2779607309 @default.
- W2037172853 hasConcept C2781065037 @default.
- W2037172853 hasConcept C2994552716 @default.
- W2037172853 hasConcept C523546767 @default.
- W2037172853 hasConcept C54355233 @default.
- W2037172853 hasConcept C547475151 @default.