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• W2037173759 abstract "This study was performed to study the role of adenosine triphosphate (ATP) in the brain of pilocarpine-induced chronic epileptic rats.ATP-mediated changes in intracellular calcium were studied by the fura-2 method. Immunohistochemistry and Western blotting methods were used to localize and quantify P2X7 receptors in these animals.The fluorimetric study in chronic rats revealed a biphasic response indicating the presence of P2X7 receptors. The Western blotting study showed an increase of 80% of P2X7 expression in chronic rats compared with the control group. P2X7 immunoreactivity resembled mossy fiber sprouting at the dentate gyrus of epileptic animals.These results suggest that purinergic receptors may participate in the pathophysiology of temporal lobe epilepsy." @default.
• W2037173759 created "2016-06-24" @default.
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• W2037173759 date "2002-07-24" @default.
• W2037173759 modified "2023-10-10" @default.
• W2037173759 title "Evidence That ATP Participates in the Pathophysiology of Pilocarpine-Induced Temporal Lobe Epilepsy: A Fluorimetric, Immunohistochemical, and Western Blot Studies" @default.
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• W2037173759 doi "https://doi.org/10.1046/j.1528-1157.43.s.5.26.x" @default.
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