FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037183937> ?p ?o ?g. }

• W2037183937 endingPage "5400" @default.
• W2037183937 startingPage "5385" @default.
• W2037183937 abstract "Nervous system-specific eve mutants were created by removing regulatory elements from a 16 kb transgene capable of complete rescue of normal eve function. When transgenes lacking the regulatory element for either RP2+a/pCC, EL or U/CQ neurons were placed in an eve-null background, eve expression was completely eliminated in the corresponding neurons, without affecting other aspects of eve expression. Many of these transgenic flies were able to survive to fertile adulthood. In the RP2+a/pCC mutant flies: (1) both RP2 and aCC showed abnormal axonal projection patterns, failing to innervate their normal target muscles; (2) the cell bodies of these neurons were positioned abnormally; and (3) in contrast to the wild type, pCC axons often crossed the midline. The Eve HD alone was able to provide a weak, partial rescue of the mutant phenotype, while both the Groucho-dependent and -independent repressor domains contributed equally to full rescue of each aspect of the mutant phenotype. Complete rescue was also obtained with a chimeric protein containing the Eve HD and the Engrailed repressor domain. Consistent with the apparent sufficiency of repressor function, a fusion protein between the Gal4 DNA-binding domain and Eve repressor domains was capable of actively repressing UAS target genes in these neurons. A key target of the repressor function of Eve was Drosophila Hb9, the derepression of which correlated with the mutant phenotype in individual eve-mutant neurons. Finally, homologues of Eve from diverse species were able to rescue the eve mutant phenotype, indicating conservation of both targeting and repression functions in the nervous system." @default.
• W2037183937 created "2016-06-24" @default.
• W2037183937 creator A5001841527 @default.
• W2037183937 creator A5009133642 @default.
• W2037183937 creator A5014859425 @default.
• W2037183937 creator A5028360947 @default.
• W2037183937 creator A5031371726 @default.
• W2037183937 creator A5034668643 @default.
• W2037183937 creator A5042740161 @default.
• W2037183937 creator A5055945854 @default.
• W2037183937 date "2003-11-15" @default.
• W2037183937 modified "2023-09-26" @default.
• W2037183937 title "Even-skipped, acting as a repressor, regulates axonal projections in <i>Drosophila</i>" @default.
• W2037183937 cites W134355853 @default.
• W2037183937 cites W1482845445 @default.
• W2037183937 cites W1515422163 @default.
• W2037183937 cites W1867052108 @default.
• W2037183937 cites W1892652257 @default.
• W2037183937 cites W1967761696 @default.
• W2037183937 cites W1975543396 @default.
• W2037183937 cites W1982037385 @default.
• W2037183937 cites W1984174621 @default.
• W2037183937 cites W1994528729 @default.
• W2037183937 cites W1997707404 @default.
• W2037183937 cites W2000572318 @default.
• W2037183937 cites W2006169062 @default.
• W2037183937 cites W2006229889 @default.
• W2037183937 cites W2012481532 @default.
• W2037183937 cites W2014479208 @default.
• W2037183937 cites W2019357185 @default.
• W2037183937 cites W2033712349 @default.
• W2037183937 cites W2035798267 @default.
• W2037183937 cites W2039728034 @default.
• W2037183937 cites W2041619316 @default.
• W2037183937 cites W2043889579 @default.
• W2037183937 cites W2051387744 @default.
• W2037183937 cites W2060943078 @default.
• W2037183937 cites W2063985696 @default.
• W2037183937 cites W2064728481 @default.
• W2037183937 cites W2069470894 @default.
• W2037183937 cites W2072570820 @default.
• W2037183937 cites W2072751609 @default.
• W2037183937 cites W2079283074 @default.
• W2037183937 cites W2079977851 @default.
• W2037183937 cites W2080698552 @default.
• W2037183937 cites W2092432413 @default.
• W2037183937 cites W2096794828 @default.
• W2037183937 cites W2109313025 @default.
• W2037183937 cites W2109775042 @default.
• W2037183937 cites W2110643873 @default.
• W2037183937 cites W2110898138 @default.
• W2037183937 cites W2120742815 @default.
• W2037183937 cites W2127262898 @default.
• W2037183937 cites W2131102224 @default.
• W2037183937 cites W2133889652 @default.
• W2037183937 cites W2140989779 @default.
• W2037183937 cites W2141267751 @default.
• W2037183937 cites W2146145315 @default.
• W2037183937 cites W2149180404 @default.
• W2037183937 cites W2149872494 @default.
• W2037183937 cites W2150478709 @default.
• W2037183937 cites W2185035960 @default.
• W2037183937 cites W2186780489 @default.
• W2037183937 cites W4063809 @default.
• W2037183937 doi "https://doi.org/10.1242/dev.00770" @default.
• W2037183937 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2709291" @default.
• W2037183937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13129849" @default.
• W2037183937 hasPublicationYear "2003" @default.
• W2037183937 type Work @default.
• W2037183937 sameAs 2037183937 @default.
• W2037183937 citedByCount "130" @default.
• W2037183937 countsByYear W20371839372012 @default.
• W2037183937 countsByYear W20371839372013 @default.
• W2037183937 countsByYear W20371839372014 @default.
• W2037183937 countsByYear W20371839372015 @default.
• W2037183937 countsByYear W20371839372016 @default.
• W2037183937 countsByYear W20371839372017 @default.
• W2037183937 countsByYear W20371839372018 @default.
• W2037183937 countsByYear W20371839372019 @default.
• W2037183937 countsByYear W20371839372020 @default.
• W2037183937 countsByYear W20371839372021 @default.
• W2037183937 countsByYear W20371839372022 @default.
• W2037183937 countsByYear W20371839372023 @default.
• W2037183937 crossrefType "journal-article" @default.
• W2037183937 hasAuthorship W2037183937A5001841527 @default.
• W2037183937 hasAuthorship W2037183937A5009133642 @default.
• W2037183937 hasAuthorship W2037183937A5014859425 @default.
• W2037183937 hasAuthorship W2037183937A5028360947 @default.
• W2037183937 hasAuthorship W2037183937A5031371726 @default.
• W2037183937 hasAuthorship W2037183937A5034668643 @default.
• W2037183937 hasAuthorship W2037183937A5042740161 @default.
• W2037183937 hasAuthorship W2037183937A5055945854 @default.
• W2037183937 hasBestOaLocation W20371839372 @default.
• W2037183937 hasConcept C102230213 @default.
• W2037183937 hasConcept C104317684 @default.
• W2037183937 hasConcept C121587040 @default.
• W2037183937 hasConcept C123894998 @default.
• W2037183937 hasConcept C127716648 @default.

• next