FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037187554> ?p ?o ?g. }

• W2037187554 endingPage "1270" @default.
• W2037187554 startingPage "1264" @default.
• W2037187554 abstract "Growth hormone (GH) deficiency is a known consequence of central nervous system irradiation. The relationship between the dose to the hypothalamus and the time to onset of clinically significant GH deficiency is unknown. Conformal radiotherapy (CRT) techniques allow for a more accurate determination of hypothalamic dosimetry. We correlated the dosimetry of the hypothalamus and the peak GH value after CRT in children with localized primary brain tumors.The arginine tolerance/L-dopa test was performed before (baseline) and repeated 6 and 12 months after CRT in 25 children (median age 4.8 years) with ependymoma (n = 15) or low-grade (n = 8) or high-grade (n = 2) astrocytoma. None had evidence of GH deficiency (arginine tolerance/L-dopa peak GH level >10 ng/mL [10 microg/L]) at baseline. Peak GH levels were modeled as a function of time after CRT and volume of the hypothalamus receiving a dose within the specified intervals of 0-20 Gy, 20-40 Gy, and 40-60 Gy. The model was used to predict the change in the peak GH levels over time (0-12 months) and fit under the assumption that the integral effect of irradiation was a linear sum of the products of the volume receiving a particular dose and the impact of that dose.The peak GH level declined during the 0-12 months after CRT (p < 0.0001). GH deficiency was observed in 11 children at 6 months and a total of 20 children at 12 months. As expected, the effect of the dose interval 0-20 Gy was smaller than the 20-40-Gy dose interval; the largest effect was noted with the dose interval 40-60 Gy. The peak GH level may be predicted using the following estimating equation within the time limit of 0-12 months: GH(t)=Exp[ln(bGH)-(0.00058V(0-20 Gy)+0.00106V(20-40 Gy)+0.00156V(40-60 Gy))x t], where bGH is the baseline peak GH level, V(0-20 Gy), V(20-40 Gy), and V(40-60 Gy) is the percent-volume of the hypothalamus irradiated from 0 to 20 Gy, 20 to 40 Gy, and 40 to 60 Gy, respectively, and t is time after irradiation. When included in the model, the rate of decline in the peak GH response also was influenced by hydrocephalus and tumor location.The peak GH response within 12 months after CRT depends on hypothalamic dose-volume effects and may be predicted on the basis of a linear model that sums the effects of the entire distribution of dose. The modeled effects may be used to optimize radiotherapy and minimize and treat GH deficiency." @default.
• W2037187554 created "2016-06-24" @default.
• W2037187554 creator A5000548058 @default.
• W2037187554 creator A5003686041 @default.
• W2037187554 creator A5006930070 @default.
• W2037187554 creator A5010322049 @default.
• W2037187554 creator A5012068082 @default.
• W2037187554 creator A5062732782 @default.
• W2037187554 creator A5064562354 @default.
• W2037187554 date "2002-04-01" @default.
• W2037187554 modified "2023-09-26" @default.
• W2037187554 title "Radiation dose-volume effects on growth hormone secretion" @default.
• W2037187554 cites W1968242722 @default.
• W2037187554 cites W2006222633 @default.
• W2037187554 cites W2019436664 @default.
• W2037187554 cites W2034203722 @default.
• W2037187554 cites W2063359548 @default.
• W2037187554 cites W2095032335 @default.
• W2037187554 cites W2096605735 @default.
• W2037187554 cites W2122800227 @default.
• W2037187554 cites W2130071028 @default.
• W2037187554 cites W2333067723 @default.
• W2037187554 doi "https://doi.org/10.1016/s0360-3016(01)02788-2" @default.
• W2037187554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11955738" @default.
• W2037187554 hasPublicationYear "2002" @default.
• W2037187554 type Work @default.
• W2037187554 sameAs 2037187554 @default.
• W2037187554 citedByCount "108" @default.
• W2037187554 countsByYear W20371875542012 @default.
• W2037187554 countsByYear W20371875542013 @default.
• W2037187554 countsByYear W20371875542014 @default.
• W2037187554 countsByYear W20371875542015 @default.
• W2037187554 countsByYear W20371875542016 @default.
• W2037187554 countsByYear W20371875542017 @default.
• W2037187554 countsByYear W20371875542018 @default.
• W2037187554 countsByYear W20371875542019 @default.
• W2037187554 countsByYear W20371875542020 @default.
• W2037187554 countsByYear W20371875542021 @default.
• W2037187554 countsByYear W20371875542022 @default.
• W2037187554 countsByYear W20371875542023 @default.
• W2037187554 crossrefType "journal-article" @default.
• W2037187554 hasAuthorship W2037187554A5000548058 @default.
• W2037187554 hasAuthorship W2037187554A5003686041 @default.
• W2037187554 hasAuthorship W2037187554A5006930070 @default.
• W2037187554 hasAuthorship W2037187554A5010322049 @default.
• W2037187554 hasAuthorship W2037187554A5012068082 @default.
• W2037187554 hasAuthorship W2037187554A5062732782 @default.
• W2037187554 hasAuthorship W2037187554A5064562354 @default.
• W2037187554 hasConcept C126322002 @default.
• W2037187554 hasConcept C134018914 @default.
• W2037187554 hasConcept C185592680 @default.
• W2037187554 hasConcept C2777003273 @default.
• W2037187554 hasConcept C2777468819 @default.
• W2037187554 hasConcept C2779952775 @default.
• W2037187554 hasConcept C2984496839 @default.
• W2037187554 hasConcept C2989005 @default.
• W2037187554 hasConcept C509974204 @default.
• W2037187554 hasConcept C515207424 @default.
• W2037187554 hasConcept C55493867 @default.
• W2037187554 hasConcept C71315377 @default.
• W2037187554 hasConcept C71924100 @default.
• W2037187554 hasConcept C75088862 @default.
• W2037187554 hasConceptScore W2037187554C126322002 @default.
• W2037187554 hasConceptScore W2037187554C134018914 @default.
• W2037187554 hasConceptScore W2037187554C185592680 @default.
• W2037187554 hasConceptScore W2037187554C2777003273 @default.
• W2037187554 hasConceptScore W2037187554C2777468819 @default.
• W2037187554 hasConceptScore W2037187554C2779952775 @default.
• W2037187554 hasConceptScore W2037187554C2984496839 @default.
• W2037187554 hasConceptScore W2037187554C2989005 @default.
• W2037187554 hasConceptScore W2037187554C509974204 @default.
• W2037187554 hasConceptScore W2037187554C515207424 @default.
• W2037187554 hasConceptScore W2037187554C55493867 @default.
• W2037187554 hasConceptScore W2037187554C71315377 @default.
• W2037187554 hasConceptScore W2037187554C71924100 @default.
• W2037187554 hasConceptScore W2037187554C75088862 @default.
• W2037187554 hasIssue "5" @default.
• W2037187554 hasLocation W20371875541 @default.
• W2037187554 hasLocation W20371875542 @default.
• W2037187554 hasOpenAccess W2037187554 @default.
• W2037187554 hasPrimaryLocation W20371875541 @default.
• W2037187554 hasRelatedWork W1982094574 @default.
• W2037187554 hasRelatedWork W2045993936 @default.
• W2037187554 hasRelatedWork W2051488242 @default.
• W2037187554 hasRelatedWork W2056116732 @default.
• W2037187554 hasRelatedWork W2066173879 @default.
• W2037187554 hasRelatedWork W2070793461 @default.
• W2037187554 hasRelatedWork W2074115578 @default.
• W2037187554 hasRelatedWork W2084435836 @default.
• W2037187554 hasRelatedWork W2471757216 @default.
• W2037187554 hasRelatedWork W2773858965 @default.
• W2037187554 hasVolume "52" @default.
• W2037187554 isParatext "false" @default.
• W2037187554 isRetracted "false" @default.
• W2037187554 magId "2037187554" @default.
• W2037187554 workType "article" @default.