Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037194989> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2037194989 endingPage "367" @default.
- W2037194989 startingPage "362" @default.
- W2037194989 abstract "Enhanced cellular glucose uptake is a frequent characteristic of malignant cells. The Akt substrate of 160 kDa (AS160) is a newly discovered substrate for the protein kinase AKT and phosphorylation of AS160 (p-AS160) was recently recognized to play an important role in glucose transport. However, studies on AS160 in cancer do not yet exist. The aim of the present study was to investigate the p-AS160 level and its correlation with clinicopathological parameters and various biological markers in breast cancer. Results showed that in breast cancer, phosphorylation of AS160 at the key residue T642 was significantly (p < 0.001) higher than that in normal adjacent tissues. P-AS160 staining was positive in 75 of 81 cases (92.6%), including 32 with weak-(score 1), 31 with moderate-(score 2) and 12 with strong immunoreactivity (score 3). P-AS160 was inversely correlated with patient age (p = 0.041) and positively correlated with tumor size (p = 0.013) and the cell proliferation marker Ki-67 (MIB-1) (p < 0.001). This is the first study of AS160 in cancer. Our results show that AS160 phosphorylation level is frequently increased in breast cancer. These results implicate a possible role of AS160 in human breast tumorigenesis and suggest that p-AS160 might be useful as a marker and a potential novel treatment target for breast cancer." @default.
- W2037194989 created "2016-06-24" @default.
- W2037194989 creator A5016455326 @default.
- W2037194989 creator A5022094185 @default.
- W2037194989 creator A5054991824 @default.
- W2037194989 creator A5060511228 @default.
- W2037194989 creator A5075369555 @default.
- W2037194989 creator A5076670414 @default.
- W2037194989 date "2010-08-15" @default.
- W2037194989 modified "2023-10-14" @default.
- W2037194989 title "Frequent hyperphosphorylation of AS160 in breast cancer" @default.
- W2037194989 doi "https://doi.org/10.4161/cbt.10.4.12426" @default.
- W2037194989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20574165" @default.
- W2037194989 hasPublicationYear "2010" @default.
- W2037194989 type Work @default.
- W2037194989 sameAs 2037194989 @default.
- W2037194989 citedByCount "9" @default.
- W2037194989 countsByYear W20371949892013 @default.
- W2037194989 countsByYear W20371949892015 @default.
- W2037194989 countsByYear W20371949892016 @default.
- W2037194989 countsByYear W20371949892017 @default.
- W2037194989 countsByYear W20371949892018 @default.
- W2037194989 countsByYear W20371949892022 @default.
- W2037194989 crossrefType "journal-article" @default.
- W2037194989 hasAuthorship W2037194989A5016455326 @default.
- W2037194989 hasAuthorship W2037194989A5022094185 @default.
- W2037194989 hasAuthorship W2037194989A5054991824 @default.
- W2037194989 hasAuthorship W2037194989A5060511228 @default.
- W2037194989 hasAuthorship W2037194989A5075369555 @default.
- W2037194989 hasAuthorship W2037194989A5076670414 @default.
- W2037194989 hasBestOaLocation W20371949891 @default.
- W2037194989 hasConcept C11960822 @default.
- W2037194989 hasConcept C121608353 @default.
- W2037194989 hasConcept C126322002 @default.
- W2037194989 hasConcept C143998085 @default.
- W2037194989 hasConcept C502942594 @default.
- W2037194989 hasConcept C530470458 @default.
- W2037194989 hasConcept C555283112 @default.
- W2037194989 hasConcept C71924100 @default.
- W2037194989 hasConcept C75217442 @default.
- W2037194989 hasConcept C86803240 @default.
- W2037194989 hasConcept C95444343 @default.
- W2037194989 hasConceptScore W2037194989C11960822 @default.
- W2037194989 hasConceptScore W2037194989C121608353 @default.
- W2037194989 hasConceptScore W2037194989C126322002 @default.
- W2037194989 hasConceptScore W2037194989C143998085 @default.
- W2037194989 hasConceptScore W2037194989C502942594 @default.
- W2037194989 hasConceptScore W2037194989C530470458 @default.
- W2037194989 hasConceptScore W2037194989C555283112 @default.
- W2037194989 hasConceptScore W2037194989C71924100 @default.
- W2037194989 hasConceptScore W2037194989C75217442 @default.
- W2037194989 hasConceptScore W2037194989C86803240 @default.
- W2037194989 hasConceptScore W2037194989C95444343 @default.
- W2037194989 hasIssue "4" @default.
- W2037194989 hasLocation W20371949891 @default.
- W2037194989 hasLocation W20371949892 @default.
- W2037194989 hasOpenAccess W2037194989 @default.
- W2037194989 hasPrimaryLocation W20371949891 @default.
- W2037194989 hasRelatedWork W1499339123 @default.
- W2037194989 hasRelatedWork W1988747615 @default.
- W2037194989 hasRelatedWork W2044529491 @default.
- W2037194989 hasRelatedWork W2080425738 @default.
- W2037194989 hasRelatedWork W2083770939 @default.
- W2037194989 hasRelatedWork W2117059884 @default.
- W2037194989 hasRelatedWork W2224319365 @default.
- W2037194989 hasRelatedWork W2904014435 @default.
- W2037194989 hasRelatedWork W3124351350 @default.
- W2037194989 hasRelatedWork W4323808922 @default.
- W2037194989 hasVolume "10" @default.
- W2037194989 isParatext "false" @default.
- W2037194989 isRetracted "false" @default.
- W2037194989 magId "2037194989" @default.
- W2037194989 workType "article" @default.