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• W2037199817 abstract "Gisbert et al.1Gisbert J.P Garcia-Buey L Pajares J.M Moreno-Otero R Prevalence of hepatitis C virus infection in B-cell non-Hodgkin’s lymphoma systematic review and meta-analysis.Gastroenterology. 2003; 125: 1723-1732Abstract Full Text Full Text PDF PubMed Scopus (260) Google Scholar in a systematic review and meta-analysis published in Gastroenterology have shown that hepatitis C virus (HCV) plays a role in the pathogenesis of B-cell non-Hodgkin lymphoma (NHL). The striking geographic association in this association suggests that genetic and/or environmental factors are also involved in the pathogenesis of this disorder. A positive association between HCV infection and NHL has been found in countries with relatively high prevalence of HCV, such as Italy, the United States, and Japan, but not in others.1Gisbert J.P Garcia-Buey L Pajares J.M Moreno-Otero R Prevalence of hepatitis C virus infection in B-cell non-Hodgkin’s lymphoma systematic review and meta-analysis.Gastroenterology. 2003; 125: 1723-1732Abstract Full Text Full Text PDF PubMed Scopus (260) Google Scholar, 2Mele A Pulsoni A Bianco E Musto P Szklo A Sanpaolo M.G Iannitto E De Renzo A Martino B Liso V Andrizzi C Pusterla S Dore F Maresca M Rapicetta M Marcucci F Mandelli F Franceschi S Hepatitis C virus and B-cell non-Hodgkin lymphomas an Italian multicenter case-control study.Blood. 2003; 102: 996-999Crossref PubMed Scopus (260) Google Scholar The prevalence of HCV infection in general population in India is low.3Chowdhury A Santra A Chaudhuri S Dhali G.K Chaudhuri S Maity S.G Naik T.N Bhattacharya S.K Mazumder D.N Hepatitis C virus infection in the general population a community-based study in West Bengal, India.Hepatology. 2003; 37: 802-809Crossref PubMed Scopus (157) Google Scholar, 4Duseja A Arora L Masih B Singh H Gupta A Behera D Chawla Y.K Dhiman R.K Hepatitis B and C virus-prevalence and prevention in health care workers.Tropical Gastroenterol. 2002; 23: 125-126PubMed Google Scholar There is no report from India assessing the relationship between HCV infection and lymphoproliferative disorders. Therefore, we decided to determine the prevalence of HCV infection in patients with NHL and chronic lymphocytic leukemia (CLL).The study population consisted of 100 consecutive patients (mean age, 45 years [range, 13–95]) with lymphoproliferative disorders (NHL and CLL) attending the Hematology-Oncology Clinic at the Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Control group consisted of 100 persons (mean age, 35 years [range, 19–50]) that included 50 voluntary blood donors and 50 relatives of the patients other than their spouses. Among the patients, 75 patients had NHL (nodal 71, primary extranodal 4); 74 patients had B-cell and 1 patient had T-cell NHL and 25 patients had CLL. The diagnosis of NHL was based on the results of lymph node biopsies in 71 patients and biopsies obtained from the stomach in 2 patients, spleen in 1, and testis in 1. Bone marrow infiltration was seen in 19 (25.4%) of these patients. Thirty-one (41.3%) patients had high-grade, 31 (41.3%) intermediate-grade, and 13 (17.4%) patients had low-grade NHL. Fifteen (20%) patients were in stage I, 17 (22.6%) in stage II, 24 (32%) in stage III and 19 (25.4%) were in stage IV. The diagnosis of CLL was based on the results of lymph node biopsies in all patients; 4 (16%) patients were in stage A, 6 (24%) in stage B, and 15 (60%) were in stage C. Sixty-one patients have either received or have been receiving the treatment with chemotherapy or radiotherapy. None of the patients received blood transfusion prior to treatment. None of the patients was an IV drug abuser or had high-risk sexual behavior. We used third-generation enzyme immunoassay (EIA-3) (DETECT-HCV, BioChem ImmunoSystems Inc., Montreal, Canada) to detect HCV antibodies. Cryoglobulins were also sought in all patients and their presence was confirmed as described elsewhere.5Pozzato G Mazzaro C Crovatto M Modolo M.L Ceselli S Mazzi G Sulfaro S Franzin F Tulissi P Moretti M Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia.Blood. 1994; 84: 3047-3053PubMed Google ScholarWhile serum sample from one patient with NHL tested positive for HCV antibodies, none of the serum samples from the controls tested positive (P = not significant, χ2 test with Yate’s correction). Thus the prevalence of HCV antibodies among patients was 1%. This patient had high-grade NHL. This patient did not receive blood transfusion in the recent past. None of the patients with CLL was positive for HCV antibodies. The patient who was positive for HCV antibodies was not positive for cryoglobulins in the serum. However, another patient with NHL showed the evidence of cryoglobulins.Our findings do not support the existence of a significant relationship between HCV infection and lymphoproliferative disorder in north India suggesting genetic and/or environmental factors may be involved primarily in the pathogenesis of this disorder in Indian patients. This is the first such study from India. The prevalence of HCV antibodies in the general population in India is low (0.8%, 0.9%).3Chowdhury A Santra A Chaudhuri S Dhali G.K Chaudhuri S Maity S.G Naik T.N Bhattacharya S.K Mazumder D.N Hepatitis C virus infection in the general population a community-based study in West Bengal, India.Hepatology. 2003; 37: 802-809Crossref PubMed Scopus (157) Google Scholar, 4Duseja A Arora L Masih B Singh H Gupta A Behera D Chawla Y.K Dhiman R.K Hepatitis B and C virus-prevalence and prevention in health care workers.Tropical Gastroenterol. 2002; 23: 125-126PubMed Google Scholar The prevalence of HCV antibodies among the patients within this study was 1%. The presence of HCV antibodies in our cohort of patients with NHL and CLL is low and more in keeping with the generally low prevalence of HCV infection in general population in India. Additional studies will, however, be needed to follow-up a large cohort of HCV-infected individuals to see if they develop lymphoproliferative disorders.In conclusion, HCV infection is not associated with lymphoproliferative disorders in northern India. HCV infection is unlikely to play a major role in the pathogenesis of lymphoproliferative disorders in India. Gisbert et al.1Gisbert J.P Garcia-Buey L Pajares J.M Moreno-Otero R Prevalence of hepatitis C virus infection in B-cell non-Hodgkin’s lymphoma systematic review and meta-analysis.Gastroenterology. 2003; 125: 1723-1732Abstract Full Text Full Text PDF PubMed Scopus (260) Google Scholar in a systematic review and meta-analysis published in Gastroenterology have shown that hepatitis C virus (HCV) plays a role in the pathogenesis of B-cell non-Hodgkin lymphoma (NHL). The striking geographic association in this association suggests that genetic and/or environmental factors are also involved in the pathogenesis of this disorder. A positive association between HCV infection and NHL has been found in countries with relatively high prevalence of HCV, such as Italy, the United States, and Japan, but not in others.1Gisbert J.P Garcia-Buey L Pajares J.M Moreno-Otero R Prevalence of hepatitis C virus infection in B-cell non-Hodgkin’s lymphoma systematic review and meta-analysis.Gastroenterology. 2003; 125: 1723-1732Abstract Full Text Full Text PDF PubMed Scopus (260) Google Scholar, 2Mele A Pulsoni A Bianco E Musto P Szklo A Sanpaolo M.G Iannitto E De Renzo A Martino B Liso V Andrizzi C Pusterla S Dore F Maresca M Rapicetta M Marcucci F Mandelli F Franceschi S Hepatitis C virus and B-cell non-Hodgkin lymphomas an Italian multicenter case-control study.Blood. 2003; 102: 996-999Crossref PubMed Scopus (260) Google Scholar The prevalence of HCV infection in general population in India is low.3Chowdhury A Santra A Chaudhuri S Dhali G.K Chaudhuri S Maity S.G Naik T.N Bhattacharya S.K Mazumder D.N Hepatitis C virus infection in the general population a community-based study in West Bengal, India.Hepatology. 2003; 37: 802-809Crossref PubMed Scopus (157) Google Scholar, 4Duseja A Arora L Masih B Singh H Gupta A Behera D Chawla Y.K Dhiman R.K Hepatitis B and C virus-prevalence and prevention in health care workers.Tropical Gastroenterol. 2002; 23: 125-126PubMed Google Scholar There is no report from India assessing the relationship between HCV infection and lymphoproliferative disorders. Therefore, we decided to determine the prevalence of HCV infection in patients with NHL and chronic lymphocytic leukemia (CLL). The study population consisted of 100 consecutive patients (mean age, 45 years [range, 13–95]) with lymphoproliferative disorders (NHL and CLL) attending the Hematology-Oncology Clinic at the Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India. Control group consisted of 100 persons (mean age, 35 years [range, 19–50]) that included 50 voluntary blood donors and 50 relatives of the patients other than their spouses. Among the patients, 75 patients had NHL (nodal 71, primary extranodal 4); 74 patients had B-cell and 1 patient had T-cell NHL and 25 patients had CLL. The diagnosis of NHL was based on the results of lymph node biopsies in 71 patients and biopsies obtained from the stomach in 2 patients, spleen in 1, and testis in 1. Bone marrow infiltration was seen in 19 (25.4%) of these patients. Thirty-one (41.3%) patients had high-grade, 31 (41.3%) intermediate-grade, and 13 (17.4%) patients had low-grade NHL. Fifteen (20%) patients were in stage I, 17 (22.6%) in stage II, 24 (32%) in stage III and 19 (25.4%) were in stage IV. The diagnosis of CLL was based on the results of lymph node biopsies in all patients; 4 (16%) patients were in stage A, 6 (24%) in stage B, and 15 (60%) were in stage C. Sixty-one patients have either received or have been receiving the treatment with chemotherapy or radiotherapy. None of the patients received blood transfusion prior to treatment. None of the patients was an IV drug abuser or had high-risk sexual behavior. We used third-generation enzyme immunoassay (EIA-3) (DETECT-HCV, BioChem ImmunoSystems Inc., Montreal, Canada) to detect HCV antibodies. Cryoglobulins were also sought in all patients and their presence was confirmed as described elsewhere.5Pozzato G Mazzaro C Crovatto M Modolo M.L Ceselli S Mazzi G Sulfaro S Franzin F Tulissi P Moretti M Low-grade malignant lymphoma, hepatitis C virus infection, and mixed cryoglobulinemia.Blood. 1994; 84: 3047-3053PubMed Google Scholar While serum sample from one patient with NHL tested positive for HCV antibodies, none of the serum samples from the controls tested positive (P = not significant, χ2 test with Yate’s correction). Thus the prevalence of HCV antibodies among patients was 1%. This patient had high-grade NHL. This patient did not receive blood transfusion in the recent past. None of the patients with CLL was positive for HCV antibodies. The patient who was positive for HCV antibodies was not positive for cryoglobulins in the serum. However, another patient with NHL showed the evidence of cryoglobulins. Our findings do not support the existence of a significant relationship between HCV infection and lymphoproliferative disorder in north India suggesting genetic and/or environmental factors may be involved primarily in the pathogenesis of this disorder in Indian patients. This is the first such study from India. The prevalence of HCV antibodies in the general population in India is low (0.8%, 0.9%).3Chowdhury A Santra A Chaudhuri S Dhali G.K Chaudhuri S Maity S.G Naik T.N Bhattacharya S.K Mazumder D.N Hepatitis C virus infection in the general population a community-based study in West Bengal, India.Hepatology. 2003; 37: 802-809Crossref PubMed Scopus (157) Google Scholar, 4Duseja A Arora L Masih B Singh H Gupta A Behera D Chawla Y.K Dhiman R.K Hepatitis B and C virus-prevalence and prevention in health care workers.Tropical Gastroenterol. 2002; 23: 125-126PubMed Google Scholar The prevalence of HCV antibodies among the patients within this study was 1%. The presence of HCV antibodies in our cohort of patients with NHL and CLL is low and more in keeping with the generally low prevalence of HCV infection in general population in India. Additional studies will, however, be needed to follow-up a large cohort of HCV-infected individuals to see if they develop lymphoproliferative disorders. In conclusion, HCV infection is not associated with lymphoproliferative disorders in northern India. HCV infection is unlikely to play a major role in the pathogenesis of lymphoproliferative disorders in India." @default.
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• W2037199817 title "Absence of hepatitis C virus infection among patients with lymphoproliferative disorders in northern India" @default.
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