FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037199854> ?p ?o ?g. }

• W2037199854 endingPage "191" @default.
• W2037199854 startingPage "181" @default.
• W2037199854 abstract "The genome of varicella-zoster virus (VZV) encodes three major families of glycoproteins (gpI, gpII, and gpIII). mRNA from VZV-infected cells was hybrid selected using a library of VZV recombinant plasmids and translated in vitro; polypeptide products were immunoprecipitated by polyclonal monospecific guinea pig antibodies to gpII. The mRNA encoding a 100-kD polypeptide precipitable by anti-gpII antibodies mapped to the HindIII D fragment near the center of the UL region. DNA sequence analysis of this region of the VZV genome revealed a 2.6-kbp open reading frame (ORF) potentially encoding a 98-kDa polypeptide possessing the characteristics of a glycoprotein. The 100-kDa polypeptide was specified by mRNA isolated by hybrid selection using a plasmid containing part of the 2.6-kbp ORF, and immunoprecipitation of this protein by anti-gpII antibodies and by convalescent zoster serum was blocked specifically by purified gpII. We conclude that the 2.6-kbp ORF encodes gpII. The imputed primary amino acid sequence of gpII shows a high degree of homology to that of herpes simplex virus type 1 (HSV-1) gB, a result consistent with the equivalent map locations of the respective genes in the HSV and VZV genomes and with the recently reported serological cross-reactivity of HSV-1 gB and VZV gpII. Unlike the mature gene products of gB, those of gpII have been described as a pair of glycoproteins with approximate molecular weights of 60 kDa in reducing gels, products of a single glycoprotein species with approximate mol mass of 125-140 kDa in nonreducing gels. Amino-terminal sequences of purified gpII were determined and compared to the imputed amino acid sequence. This comparison implies that the primary translational product is cleaved approximately into halves in vivo and suggests that mature gpII is a disulfide-linked heterodimer." @default.
• W2037199854 created "2016-06-24" @default.
• W2037199854 creator A5001365051 @default.
• W2037199854 creator A5013814509 @default.
• W2037199854 creator A5015239758 @default.
• W2037199854 creator A5039230558 @default.
• W2037199854 creator A5040906660 @default.
• W2037199854 date "1986-07-01" @default.
• W2037199854 modified "2023-10-16" @default.
• W2037199854 title "Identification and structure of the gene encoding gpII, a major glycoprotein of varicella-zoster virus" @default.
• W2037199854 cites W114186034 @default.
• W2037199854 cites W1486036290 @default.
• W2037199854 cites W1506396477 @default.
• W2037199854 cites W1562382257 @default.
• W2037199854 cites W1600871831 @default.
• W2037199854 cites W1645614786 @default.
• W2037199854 cites W1645986795 @default.
• W2037199854 cites W1666232342 @default.
• W2037199854 cites W1743073606 @default.
• W2037199854 cites W1827464375 @default.
• W2037199854 cites W1898273578 @default.
• W2037199854 cites W1902367528 @default.
• W2037199854 cites W1961797414 @default.
• W2037199854 cites W1964331418 @default.
• W2037199854 cites W1966091169 @default.
• W2037199854 cites W1975304761 @default.
• W2037199854 cites W1992945652 @default.
• W2037199854 cites W2000969325 @default.
• W2037199854 cites W2005966253 @default.
• W2037199854 cites W2018049270 @default.
• W2037199854 cites W2049992691 @default.
• W2037199854 cites W2054468433 @default.
• W2037199854 cites W2055116598 @default.
• W2037199854 cites W2060333964 @default.
• W2037199854 cites W2063466305 @default.
• W2037199854 cites W2063651512 @default.
• W2037199854 cites W2076307009 @default.
• W2037199854 cites W2077224012 @default.
• W2037199854 cites W2088593543 @default.
• W2037199854 cites W2092371358 @default.
• W2037199854 cites W2097318833 @default.
• W2037199854 cites W2138006485 @default.
• W2037199854 cites W2152825059 @default.
• W2037199854 cites W2159293959 @default.
• W2037199854 cites W2160464134 @default.
• W2037199854 cites W2161666969 @default.
• W2037199854 cites W2169088659 @default.
• W2037199854 cites W2175970545 @default.
• W2037199854 doi "https://doi.org/10.1016/0042-6822(86)90383-1" @default.
• W2037199854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3029986" @default.
• W2037199854 hasPublicationYear "1986" @default.
• W2037199854 type Work @default.
• W2037199854 sameAs 2037199854 @default.
• W2037199854 citedByCount "126" @default.
• W2037199854 countsByYear W20371998542019 @default.
• W2037199854 crossrefType "journal-article" @default.
• W2037199854 hasAuthorship W2037199854A5001365051 @default.
• W2037199854 hasAuthorship W2037199854A5013814509 @default.
• W2037199854 hasAuthorship W2037199854A5015239758 @default.
• W2037199854 hasAuthorship W2037199854A5039230558 @default.
• W2037199854 hasAuthorship W2037199854A5040906660 @default.
• W2037199854 hasConcept C104317684 @default.
• W2037199854 hasConcept C108625454 @default.
• W2037199854 hasConcept C153911025 @default.
• W2037199854 hasConcept C159047783 @default.
• W2037199854 hasConcept C159654299 @default.
• W2037199854 hasConcept C167625842 @default.
• W2037199854 hasConcept C22744801 @default.
• W2037199854 hasConcept C2522874641 @default.
• W2037199854 hasConcept C2781196997 @default.
• W2037199854 hasConcept C47289529 @default.
• W2037199854 hasConcept C54355233 @default.
• W2037199854 hasConcept C86803240 @default.
• W2037199854 hasConcept C956191 @default.
• W2037199854 hasConceptScore W2037199854C104317684 @default.
• W2037199854 hasConceptScore W2037199854C108625454 @default.
• W2037199854 hasConceptScore W2037199854C153911025 @default.
• W2037199854 hasConceptScore W2037199854C159047783 @default.
• W2037199854 hasConceptScore W2037199854C159654299 @default.
• W2037199854 hasConceptScore W2037199854C167625842 @default.
• W2037199854 hasConceptScore W2037199854C22744801 @default.
• W2037199854 hasConceptScore W2037199854C2522874641 @default.
• W2037199854 hasConceptScore W2037199854C2781196997 @default.
• W2037199854 hasConceptScore W2037199854C47289529 @default.
• W2037199854 hasConceptScore W2037199854C54355233 @default.
• W2037199854 hasConceptScore W2037199854C86803240 @default.
• W2037199854 hasConceptScore W2037199854C956191 @default.
• W2037199854 hasIssue "1" @default.
• W2037199854 hasLocation W20371998541 @default.
• W2037199854 hasLocation W20371998542 @default.
• W2037199854 hasOpenAccess W2037199854 @default.
• W2037199854 hasPrimaryLocation W20371998541 @default.
• W2037199854 hasRelatedWork W1571771606 @default.
• W2037199854 hasRelatedWork W1993339219 @default.
• W2037199854 hasRelatedWork W2038801503 @default.
• W2037199854 hasRelatedWork W2055706740 @default.
• W2037199854 hasRelatedWork W2057824115 @default.
• W2037199854 hasRelatedWork W2066091494 @default.

• next