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- W2037200069 abstract "Abstract Thiouracil and thyroxine (T 4 ) were injected onto the chick chorioallantois at various developmental stages to study their effects on corneal cellularity, dehydration and structure. Corneas were excised 2–9 days after treatment for histological examination and for analyses of water content, sodium concentration [Na + ] and potassium concentration [K + ]. Untreated chick corneas showed that water content and [Na + ] decreased with advancing embryonic age, while [K + ] increased up to stage 42 and then rapidly declined. Corneas from embryos injected with 10 mg thiouracil at stage 36 had a significantly reduced [K + ] at stages 40 and 42. Corneas at stages 40, 42 and 45 had a significantly elevated water content when compared with controls. Injection of 15 μg of T 4 prior to stage 36 or at or after stage 40 did not produce significant changes in corneal water and ionic content compared with controls; injection of 15 μg of T 4 during the cell proliferation period of corneal development (stages 36–40) produced a significant increase in [K + ]. Similar results were obtained in corneas from embryos injected with 1 μg of T 4 . Total corneal thickness was increased in thiouracil treated corneas, and decreased in T 4 treated corneas. Epithelial growth was markedly decreased with thiouracil treatment, while T 4 had little effect. It is likely that thiouracil treatment decreases cell division in the cornea, and prevents formation of the epithelial barrier, whereas T 4 accelerates these processes." @default.
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- W2037200069 date "1975-04-01" @default.
- W2037200069 modified "2023-09-24" @default.
- W2037200069 title "Development of cornel transparency in embryonic chick: Influence of exogenous thyroxine and thiouracil on structure, water and electrolyte content" @default.
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- W2037200069 doi "https://doi.org/10.1016/0012-1606(75)90023-8" @default.
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