FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037206515> ?p ?o ?g. }

• W2037206515 endingPage "32002" @default.
• W2037206515 startingPage "31995" @default.
• W2037206515 abstract "SIRT4, a member of the sirtuin family, has been implicated in the regulation of insulin secretion by modulation of glutamate dehydrogenase. However, the role of this enzyme in the regulation of metabolism in other tissues is unknown. In this study we investigated whether depletion of SIRT4 would enhance liver and muscle metabolic functions. To do this SIRT4 was knocked down using an adenoviral shRNA in mouse primary hepatocytes and myotubes. We observed a significant increase in gene expression of mitochondrial and fatty acid metabolism enzymes in hepatocytes with reduced SIRT4 levels. SIRT4 knockdown also increased SIRT1 mRNA and protein levels both in vitro and in vivo. In agreement with the increased fatty acid oxidation (FAO) gene expression, we showed a significant increase in FAO in SIRT4 knockdown primary hepatocytes compared with control, and this effect was dependent on SIRT1. In primary myotubes, knockdown of SIRT4 resulted in increased FAO, cellular respiration, and pAMPK levels. When SIRT4 was knocked down in vivo by tail vein injection of a shRNA adenovirus, we observed a significant increase in hepatic mitochondrial and FAO gene expression consistent with the findings in primary hepatocytes. Taken together these findings demonstrate that SIRT4 inhibition increases fat oxidative capacity in liver and mitochondrial function in muscle, which might provide therapeutic benefits for diseases associated with ectopic lipid storage such as type 2 diabetes." @default.
• W2037206515 created "2016-06-24" @default.
• W2037206515 creator A5013699712 @default.
• W2037206515 creator A5016591535 @default.
• W2037206515 creator A5021878531 @default.
• W2037206515 creator A5031210114 @default.
• W2037206515 creator A5046784225 @default.
• W2037206515 creator A5051775964 @default.
• W2037206515 creator A5068403328 @default.
• W2037206515 creator A5088734920 @default.
• W2037206515 creator A5089585125 @default.
• W2037206515 creator A5091730609 @default.
• W2037206515 date "2010-10-01" @default.
• W2037206515 modified "2023-10-15" @default.
• W2037206515 title "SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells" @default.
• W2037206515 cites W1502860001 @default.
• W2037206515 cites W1566805734 @default.
• W2037206515 cites W1973163466 @default.
• W2037206515 cites W1974077150 @default.
• W2037206515 cites W2005789183 @default.
• W2037206515 cites W2015022497 @default.
• W2037206515 cites W2016294119 @default.
• W2037206515 cites W2022267544 @default.
• W2037206515 cites W2032983681 @default.
• W2037206515 cites W2044578262 @default.
• W2037206515 cites W2052751736 @default.
• W2037206515 cites W2053213876 @default.
• W2037206515 cites W2056673958 @default.
• W2037206515 cites W2058768220 @default.
• W2037206515 cites W2083434423 @default.
• W2037206515 cites W2105083182 @default.
• W2037206515 cites W2117473844 @default.
• W2037206515 cites W2118964113 @default.
• W2037206515 cites W2123016403 @default.
• W2037206515 cites W2143687302 @default.
• W2037206515 cites W2152101492 @default.
• W2037206515 doi "https://doi.org/10.1074/jbc.m110.124164" @default.
• W2037206515 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2952200" @default.
• W2037206515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20685656" @default.
• W2037206515 hasPublicationYear "2010" @default.
• W2037206515 type Work @default.
• W2037206515 sameAs 2037206515 @default.
• W2037206515 citedByCount "265" @default.
• W2037206515 countsByYear W20372065152012 @default.
• W2037206515 countsByYear W20372065152013 @default.
• W2037206515 countsByYear W20372065152014 @default.
• W2037206515 countsByYear W20372065152015 @default.
• W2037206515 countsByYear W20372065152016 @default.
• W2037206515 countsByYear W20372065152017 @default.
• W2037206515 countsByYear W20372065152018 @default.
• W2037206515 countsByYear W20372065152019 @default.
• W2037206515 countsByYear W20372065152020 @default.
• W2037206515 countsByYear W20372065152021 @default.
• W2037206515 countsByYear W20372065152022 @default.
• W2037206515 countsByYear W20372065152023 @default.
• W2037206515 crossrefType "journal-article" @default.
• W2037206515 hasAuthorship W2037206515A5013699712 @default.
• W2037206515 hasAuthorship W2037206515A5016591535 @default.
• W2037206515 hasAuthorship W2037206515A5021878531 @default.
• W2037206515 hasAuthorship W2037206515A5031210114 @default.
• W2037206515 hasAuthorship W2037206515A5046784225 @default.
• W2037206515 hasAuthorship W2037206515A5051775964 @default.
• W2037206515 hasAuthorship W2037206515A5068403328 @default.
• W2037206515 hasAuthorship W2037206515A5088734920 @default.
• W2037206515 hasAuthorship W2037206515A5089585125 @default.
• W2037206515 hasAuthorship W2037206515A5091730609 @default.
• W2037206515 hasBestOaLocation W20372065151 @default.
• W2037206515 hasConcept C104317684 @default.
• W2037206515 hasConcept C134018914 @default.
• W2037206515 hasConcept C150194340 @default.
• W2037206515 hasConcept C153911025 @default.
• W2037206515 hasConcept C173396325 @default.
• W2037206515 hasConcept C190232843 @default.
• W2037206515 hasConcept C207200792 @default.
• W2037206515 hasConcept C28859421 @default.
• W2037206515 hasConcept C3763915 @default.
• W2037206515 hasConcept C543025807 @default.
• W2037206515 hasConcept C55493867 @default.
• W2037206515 hasConcept C82714985 @default.
• W2037206515 hasConcept C86803240 @default.
• W2037206515 hasConcept C97037327 @default.
• W2037206515 hasConceptScore W2037206515C104317684 @default.
• W2037206515 hasConceptScore W2037206515C134018914 @default.
• W2037206515 hasConceptScore W2037206515C150194340 @default.
• W2037206515 hasConceptScore W2037206515C153911025 @default.
• W2037206515 hasConceptScore W2037206515C173396325 @default.
• W2037206515 hasConceptScore W2037206515C190232843 @default.
• W2037206515 hasConceptScore W2037206515C207200792 @default.
• W2037206515 hasConceptScore W2037206515C28859421 @default.
• W2037206515 hasConceptScore W2037206515C3763915 @default.
• W2037206515 hasConceptScore W2037206515C543025807 @default.
• W2037206515 hasConceptScore W2037206515C55493867 @default.
• W2037206515 hasConceptScore W2037206515C82714985 @default.
• W2037206515 hasConceptScore W2037206515C86803240 @default.
• W2037206515 hasConceptScore W2037206515C97037327 @default.
• W2037206515 hasIssue "42" @default.
• W2037206515 hasLocation W20372065151 @default.
• W2037206515 hasLocation W20372065152 @default.

• next