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• W2037213176 abstract "The widespread use of benzodiazepines has led to increasing recognition of their unwanted effects. The efficacy of alprazolam and placebo in panic disorder with agoraphobia, and the side-effect and adverse effect profiles of both drug groups were measured.In London and Toronto 154 patients who met DSM-III criteria for panic disorder with agoraphobia were randomised to alprazolam or placebo. Subjects in each drug group also received either exposure or relaxation. Treatment was from weeks 0 to 8 and was then tapered from weeks 8 to 16.Mean alprazolam dose was 5 mg daily. Compared with placebo subjects, alprazolam patients developed more adverse reactions (21% v. 0%) of depression, enuresis, disinhibition and aggression; and more side-effects, particularly sedation, irritability, impaired memory, weight loss and ataxia. Side-effects tended to diminish during treatment but remained significant at week 8. Despite this, the drop-out rate was low.Alprazolam caused side-effects and adverse effects during treatment but many patients were willing to accept these." @default.
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• W2037213176 date "1994-07-01" @default.
• W2037213176 modified "2023-10-17" @default.
• W2037213176 title "Safety and Side-effects of Alprazolam Controlled Study in Agoraphobia with Panic Disorder" @default.
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• W2037213176 doi "https://doi.org/10.1192/bjp.165.1.79" @default.
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