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- W2037215908 endingPage "184" @default.
- W2037215908 startingPage "165" @default.
- W2037215908 abstract "The treatment paradigm of several cancers has dramatically changed in recent years with the introduction of immunotherapy. Most oncology trials involving immune checkpoint inhibitors (ICIPs) have routinely excluded patients with HIV infection and chronic viral hepatitis B (HBV) and C (HCV) due to concerns about viral reactivation, fears of increased toxicity, and the potential lack of efficacy in these patient subgroups. However, with current antiviral therapies, HIV and HBV infections have become chronic diseases and HCV infections can even be cured. Broadening cancer trial eligibility criteria in order to include cancer patients with chronic viral infections can maximize the ecological validity of study results and the ability to understand the ICPIs’ benefit-risk profile in patients with these comorbidities. In this review, we examined the evidence on the efficacy and safety of using ICPIs in cancer patients with concurrent chronic viral infections." @default.
- W2037215908 created "2016-06-24" @default.
- W2037215908 creator A5021793394 @default.
- W2037215908 creator A5038699632 @default.
- W2037215908 creator A5045745778 @default.
- W2037215908 creator A5046311100 @default.
- W2037215908 creator A5061054780 @default.
- W2037215908 date "1996-11-01" @default.
- W2037215908 modified "2023-09-27" @default.
- W2037215908 title "Malignant tumors in patients with HIV infection" @default.
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