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• W2037216960 abstract "Eaf2 encodes a tumor suppressor that plays multiple functions in transcriptional activation, apoptosis, and embryonic development. In this study, we utilized GFP-EAF2 fusion protein to describe the dynamic subcellular movement of Eaf2. GFP-EAF2 is preferentially localized to the nucleus, and in the presence of ELL, it accumulates in nuclear speckles. However, Eaf2 is an unstable nuclear protein whose stability is affected by serum. Further, we provided first evidence that nuclear distribution of Eaf2 is responsive to DNA damage. Following UV irradiation, Eaf2 is relocalized to the nucleolus, suggesting a possible functional involvement of Eaf2 in DNA damage response." @default.
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• W2037216960 date "2008-12-01" @default.
• W2037216960 modified "2023-10-15" @default.
• W2037216960 title "Dynamic Intracellular Distribution of Eaf2 and Its Potential Involvement in UV-Induced DNA Damage Response" @default.
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• W2037216960 doi "https://doi.org/10.1089/dna.2008.0733" @default.
• W2037216960 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2668985" @default.
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