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- W2037219135 abstract "Background: Candida species are opportunistic pathogens that cause superficial and systemic candidiasis particularly in immunocompromised patients. Resistance to many clinically used antifungal agents has created a need to identify new compounds and develop drugs for therapeutic use. Therefore, the main objective was to carry out bioguided fractionation of the ethanolic and aqueous extracts of the leaves, twigs, stem, stembark and trunck of Uvariodendron calophyllum. Methods & Materials: The leaves were macerated in ethanol and water, their yields of extraction were calculated. The broth micro dilution method was used for antifungal susceptibility testing of yeasts (Candida albicans, Candida glabrata, Candida parapsilosis, Cryptococcus neoformans isolates and four candida albicans strainsATCCL26, ATCC 12C, ATCC P37039, ATCC P37037). Phytochemical screening on the crude extracts was done. Then, bioguided fractionation was done on the crude extracts using Hexane, Methylene Chloride and Methanol. Column chromatography was done on the methylene chloride fraction of the leaf ethanolic extract using different solvent systems. Results: The yields of extraction ranged from 1.125% to 6.77% for the aqueous extract and from 3.57% to 10.67% for the ethanol extracts. The phytochemical screening showed the presence of phenols, tannins, flavonoids and glycosides in both extracts. The MIC ranged from 0.63 ± 0.27 to 2.19 ± 1.43 mg/mL for the ethanol extracts, from 1.88 ± 0.00 to 7.50 ± 0.00 mg/mL for the aqueous extract on the tested microorganisms. 35 fractions were obtained after partition and their MIC results ranged from 1.25 ± 0.00 to ≥10 ± 0.00 mg/mL on the tested microorganisms. Nineteen fractions were obtained and labeled fraction A to fraction S with MIC varying from 0.002 to ≥2 mg/mL with fraction S having the best activity. Conclusion: The crude ethanol, aqueous extracts and fractions of Uvariodendron calophyllum could be potential sources of compounds with anti-yeastactivity." @default.
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- W2037219135 date "2014-04-01" @default.
- W2037219135 modified "2023-09-28" @default.
- W2037219135 title "Anti-yeast activity of Uvariodendron calophyllumfractions" @default.
- W2037219135 doi "https://doi.org/10.1016/j.ijid.2014.03.1017" @default.
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