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- W2037221413 abstract "Using intracellular microelectrodes, we investigated whether 8-bromo-gaunosine 3′:5′-cyclic monophosphate (cGMP) influenced the electromechanical effects of tetraethylammonium (TEA) on canine trache smooth muscle. We found that 20 mM TEA depolarized airway smooth muscle cells from −58±3 mV (means ± S.D.) to −44±2 mV and caused spontaneous action potentials (APs) to develop which were 31±2 mV in amplitude. These APs, and the phasic contractions electrically coupled to them, were totally abolished in buffer containing 0.1 mM cGMP. Our findings suggest that cGMP markedly affects the channels mediating TEA-induced APs in airway smooth muscle." @default.
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- W2037221413 date "1986-09-01" @default.
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- W2037221413 title "8-Bromo-cyclic GMP abolishes TEA-induced slow actions potential in canine trachealis muscle" @default.
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- W2037221413 doi "https://doi.org/10.1016/0014-2999(86)90783-1" @default.
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