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- W2037221785 abstract "We studied the effects of in vitro X-irradiation on human sperm chromosomes, using our interspecific in vitro fertilization system based human spermatozoa and zona-free oocytes. 28 semen samples from 5 healthy men were exposed to 0.23, 0.45, 0.91 and 1.82 Gy of X-rays. Totals of 2098 and 2862 spermatozoa were karyotyped in the control and the irradiated groups, respectively. The incidence of spermatozoa with X-ray-induced structural chromosome aberrations (Y) increased linearly with increasing dosage (D), being best expressed the equation, Y = 0.08 + 34.52 D. The incidence of breakage-type aberrations was more than 9 times higher than that of exchange-type aberrations. Both of them showed linear dose-dependent increases, which were expressed by the regression lines, Y = −0.014 + 0.478 D and Y = 0.010 + 0.057 D, respectively. The incidence of chromosome-type aberrations was about 6 times higher than that of chromatid-type aberrations. Their dose-dependent increases were expressed by the regression lines, Y = −0.015 + 0.462 D and Y = −0.006 + 0.079 D, respectively. These results are discussed in relation to the previous data obtained with γ-rays. The repair mechanism of X-ray-induced sperm DNA lesions is also discussed." @default.
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- W2037221785 date "1990-02-01" @default.
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- W2037221785 title "Types of structural chromosome aberrations and their incidences in human spermatozoa X-irradiated in vitro" @default.
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- W2037221785 doi "https://doi.org/10.1016/0027-5107(90)90069-g" @default.
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