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• W2037227352 abstract "P-glycoprotein (P-gp) is one of the ATP-binding cassette transporters and acts as an efflux pump for cytotoxic substances. P-gp mRNA expression and transporting activity show the daily rhythm and contribute to the chrono-pharmacokinetic profiles of many drugs. It is reported that the daily rhythm of <i>abcb1a</i> mRNA is regulated by a circadian clock-controlled output pathway. Time-restricted feeding is well known to shift the peripheral circadian phase of clock gene expression without changing the central clock function. This study was undertaken to examine the influence of a time-restricted feeding procedure during the light phase on the daily rhythms of <i>abcb1a</i> mRNA expression and P-gp activity. The <i>abcb1a</i> mRNA and P-gp activity showed a daily rhythm with a peak early in the dark phase in rat intestine under ad libitum feeding. Time-restricted feeding during the light phase shifted these rhythms to 12-h advance. The mRNA expression of clock genes (<i>DBP</i> and <i>HLF</i>, the transcript activators of <i>abcb1a</i>) also showed daily rhythms, and their phases were shifted by the time-restricted feeding procedure. The peak time of <i>DBP</i> mRNA expression was similar to that of <i>abcb1a</i> mRNA expression under ad libitum feeding and time-restricted feeding conditions. These results indicate that a time-restricted feeding procedure changes <i>DBP</i> mRNA expression, which in turn influences <i>abcb1a</i> mRNA expression and P-gp activity." @default.
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• W2037227352 date "2010-07-28" @default.
• W2037227352 modified "2023-09-26" @default.
• W2037227352 title "Influence of a Time-Restricted Feeding Schedule on the Daily Rhythm of <i>abcb1a</i> Gene Expression and Its Function in Rat Intestine" @default.
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• W2037227352 doi "https://doi.org/10.1124/jpet.110.170837" @default.
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