FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037228519> ?p ?o ?g. }

• W2037228519 endingPage "4484" @default.
• W2037228519 startingPage "4477" @default.
• W2037228519 abstract "Excessive scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing. Much experimental data suggests that prostaglandin E2 (PGE2) plays a role in the prevention of excessive scarring. However, it has a very short half-live in blood, its oxidization to 15-ketoprostaglandins is catalyzed by 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Previously, we reported that 15-PGDH inhibitors significantly increased PGE2 levels in A549 cells. In our continuing attempts to develop highly potent 15-PGDH inhibitors, we newly synthesized various thiazolidine-2,4-dione derivatives. Compound 27, 28, 29, and 30 demonstrated IC50 values of 0.048, 0.020, 0.038 and 0.048 μM, respectively. They also increased levels of PGE2 in A549 cells. Especially, compound 28 significantly increased level of PGE2 at 260 pg/mL, which was approximately fivefold higher than that of control. Scratch wounds were analyzed in confluent monolayers of HaCaT cells. Cells exposed to compound 28 showed significantly improved wound healing with respect to control." @default.
• W2037228519 created "2016-06-24" @default.
• W2037228519 creator A5003865202 @default.
• W2037228519 creator A5033515697 @default.
• W2037228519 creator A5035363799 @default.
• W2037228519 creator A5039504801 @default.
• W2037228519 date "2013-08-01" @default.
• W2037228519 modified "2023-10-17" @default.
• W2037228519 title "Control of the intracellular levels of prostaglandin E2 through inhibition of the 15-hydroxyprostaglandin dehydrogenase for wound healing" @default.
• W2037228519 cites W1520422464 @default.
• W2037228519 cites W1563552860 @default.
• W2037228519 cites W178453547 @default.
• W2037228519 cites W1931315964 @default.
• W2037228519 cites W1965038379 @default.
• W2037228519 cites W1973171523 @default.
• W2037228519 cites W1976142040 @default.
• W2037228519 cites W1981743642 @default.
• W2037228519 cites W1989021197 @default.
• W2037228519 cites W1995721099 @default.
• W2037228519 cites W2026720471 @default.
• W2037228519 cites W2028929625 @default.
• W2037228519 cites W2042803584 @default.
• W2037228519 cites W2048599583 @default.
• W2037228519 cites W2083147596 @default.
• W2037228519 cites W2088077685 @default.
• W2037228519 cites W2090677394 @default.
• W2037228519 cites W2095003431 @default.
• W2037228519 cites W2111598062 @default.
• W2037228519 cites W2134050771 @default.
• W2037228519 cites W2169804443 @default.
• W2037228519 cites W2951325173 @default.
• W2037228519 cites W2952157156 @default.
• W2037228519 doi "https://doi.org/10.1016/j.bmc.2013.05.049" @default.
• W2037228519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23791868" @default.
• W2037228519 hasPublicationYear "2013" @default.
• W2037228519 type Work @default.
• W2037228519 sameAs 2037228519 @default.
• W2037228519 citedByCount "15" @default.
• W2037228519 countsByYear W20372285192014 @default.
• W2037228519 countsByYear W20372285192015 @default.
• W2037228519 countsByYear W20372285192017 @default.
• W2037228519 countsByYear W20372285192018 @default.
• W2037228519 countsByYear W20372285192019 @default.
• W2037228519 countsByYear W20372285192020 @default.
• W2037228519 countsByYear W20372285192021 @default.
• W2037228519 countsByYear W20372285192022 @default.
• W2037228519 crossrefType "journal-article" @default.
• W2037228519 hasAuthorship W2037228519A5003865202 @default.
• W2037228519 hasAuthorship W2037228519A5033515697 @default.
• W2037228519 hasAuthorship W2037228519A5035363799 @default.
• W2037228519 hasAuthorship W2037228519A5039504801 @default.
• W2037228519 hasBestOaLocation W20372285191 @default.
• W2037228519 hasConcept C118995209 @default.
• W2037228519 hasConcept C134018914 @default.
• W2037228519 hasConcept C185592680 @default.
• W2037228519 hasConcept C189165786 @default.
• W2037228519 hasConcept C202751555 @default.
• W2037228519 hasConcept C203014093 @default.
• W2037228519 hasConcept C2777198256 @default.
• W2037228519 hasConcept C2777752497 @default.
• W2037228519 hasConcept C2777956040 @default.
• W2037228519 hasConcept C2780269544 @default.
• W2037228519 hasConcept C2780664492 @default.
• W2037228519 hasConcept C55493867 @default.
• W2037228519 hasConcept C71924100 @default.
• W2037228519 hasConcept C79879829 @default.
• W2037228519 hasConcept C81729549 @default.
• W2037228519 hasConcept C98274493 @default.
• W2037228519 hasConceptScore W2037228519C118995209 @default.
• W2037228519 hasConceptScore W2037228519C134018914 @default.
• W2037228519 hasConceptScore W2037228519C185592680 @default.
• W2037228519 hasConceptScore W2037228519C189165786 @default.
• W2037228519 hasConceptScore W2037228519C202751555 @default.
• W2037228519 hasConceptScore W2037228519C203014093 @default.
• W2037228519 hasConceptScore W2037228519C2777198256 @default.
• W2037228519 hasConceptScore W2037228519C2777752497 @default.
• W2037228519 hasConceptScore W2037228519C2777956040 @default.
• W2037228519 hasConceptScore W2037228519C2780269544 @default.
• W2037228519 hasConceptScore W2037228519C2780664492 @default.
• W2037228519 hasConceptScore W2037228519C55493867 @default.
• W2037228519 hasConceptScore W2037228519C71924100 @default.
• W2037228519 hasConceptScore W2037228519C79879829 @default.
• W2037228519 hasConceptScore W2037228519C81729549 @default.
• W2037228519 hasConceptScore W2037228519C98274493 @default.
• W2037228519 hasIssue "15" @default.
• W2037228519 hasLocation W20372285191 @default.
• W2037228519 hasLocation W20372285192 @default.
• W2037228519 hasOpenAccess W2037228519 @default.
• W2037228519 hasPrimaryLocation W20372285191 @default.
• W2037228519 hasRelatedWork W1672254856 @default.
• W2037228519 hasRelatedWork W1988204763 @default.
• W2037228519 hasRelatedWork W2037228519 @default.
• W2037228519 hasRelatedWork W2048022180 @default.
• W2037228519 hasRelatedWork W2084670112 @default.
• W2037228519 hasRelatedWork W2150823738 @default.
• W2037228519 hasRelatedWork W2296610671 @default.
• W2037228519 hasRelatedWork W2416165761 @default.
• W2037228519 hasRelatedWork W2417810821 @default.

• next