FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2037229788> ?p ?o ?g. }

• W2037229788 endingPage "304" @default.
• W2037229788 startingPage "296" @default.
• W2037229788 abstract "Recent advances in genotyping technology and in particular a number of large-scale genome-wide association studies have helped to unravel the genetic basis of hypertension. Although our knowledge is still far from being complete it is important to ask how genetic findings could be translated to clinical practice. In a first step we summarize the strategies to dissect the genetics of hypertension from candidate gene studies to genome-wide association studies and recent sequencing experiments. The greatest hope in this context is the development of new drugs that are based on newly discovered pathophysiological principles. We describe examples where significant therapeutic effects are achieved with agents targeting pathways that contribute only small amounts to the genetic variability of a phenotype. There are good reasons to believe that new drugs will be developed based on genetic data in hypertension. We also highlight the potential for pharmacogenetics and risk stratification. The former is not currently supported by a larger body of evidence, but well designed studies are under way. The latter needs to follow the same principles for evaluation of other novel biomarkers of cardiovascular risk and is unlikely to influence clinical practice in the next few years." @default.
• W2037229788 created "2016-06-24" @default.
• W2037229788 creator A5016286778 @default.
• W2037229788 creator A5040449404 @default.
• W2037229788 date "2012-05-01" @default.
• W2037229788 modified "2023-09-30" @default.
• W2037229788 title "Genetics and Hypertension: Is It Time to Change My Practice?" @default.
• W2037229788 cites W1576715128 @default.
• W2037229788 cites W1604547439 @default.
• W2037229788 cites W1963873811 @default.
• W2037229788 cites W1967490910 @default.
• W2037229788 cites W1967497562 @default.
• W2037229788 cites W1976235415 @default.
• W2037229788 cites W1996322545 @default.
• W2037229788 cites W1997849573 @default.
• W2037229788 cites W1998674200 @default.
• W2037229788 cites W2001629081 @default.
• W2037229788 cites W2007081766 @default.
• W2037229788 cites W2009365265 @default.
• W2037229788 cites W2019398709 @default.
• W2037229788 cites W2020934198 @default.
• W2037229788 cites W2027299227 @default.
• W2037229788 cites W2029922343 @default.
• W2037229788 cites W2030068099 @default.
• W2037229788 cites W2030078530 @default.
• W2037229788 cites W2033041275 @default.
• W2037229788 cites W2037590835 @default.
• W2037229788 cites W2046838656 @default.
• W2037229788 cites W2051505451 @default.
• W2037229788 cites W2052362972 @default.
• W2037229788 cites W2054153086 @default.
• W2037229788 cites W2054538825 @default.
• W2037229788 cites W2059846045 @default.
• W2037229788 cites W2062199687 @default.
• W2037229788 cites W2064310756 @default.
• W2037229788 cites W2066344678 @default.
• W2037229788 cites W2071157235 @default.
• W2037229788 cites W2087117816 @default.
• W2037229788 cites W2088903836 @default.
• W2037229788 cites W2094811234 @default.
• W2037229788 cites W2101605059 @default.
• W2037229788 cites W2102622802 @default.
• W2037229788 cites W2105066453 @default.
• W2037229788 cites W2105318826 @default.
• W2037229788 cites W2110085945 @default.
• W2037229788 cites W2110171695 @default.
• W2037229788 cites W2117925356 @default.
• W2037229788 cites W2120798274 @default.
• W2037229788 cites W2121308112 @default.
• W2037229788 cites W2123869079 @default.
• W2037229788 cites W2124019549 @default.
• W2037229788 cites W2126841225 @default.
• W2037229788 cites W2127110761 @default.
• W2037229788 cites W2129254992 @default.
• W2037229788 cites W2130383679 @default.
• W2037229788 cites W2130542470 @default.
• W2037229788 cites W2134662886 @default.
• W2037229788 cites W2134783591 @default.
• W2037229788 cites W2135225292 @default.
• W2037229788 cites W2136150492 @default.
• W2037229788 cites W2139848602 @default.
• W2037229788 cites W2140079333 @default.
• W2037229788 cites W2140609764 @default.
• W2037229788 cites W2140733217 @default.
• W2037229788 cites W2141784797 @default.
• W2037229788 cites W2141913464 @default.
• W2037229788 cites W2147016415 @default.
• W2037229788 cites W2147158921 @default.
• W2037229788 cites W2159923031 @default.
• W2037229788 cites W2160294128 @default.
• W2037229788 cites W2161935988 @default.
• W2037229788 cites W2163794114 @default.
• W2037229788 cites W2164212257 @default.
• W2037229788 cites W2165055255 @default.
• W2037229788 cites W2166672278 @default.
• W2037229788 cites W2167893037 @default.
• W2037229788 cites W2168357775 @default.
• W2037229788 cites W2169314667 @default.
• W2037229788 cites W2171396537 @default.
• W2037229788 cites W2208236539 @default.
• W2037229788 cites W2331536812 @default.
• W2037229788 cites W4211079492 @default.
• W2037229788 cites W4254209755 @default.
• W2037229788 cites W75245760 @default.
• W2037229788 doi "https://doi.org/10.1016/j.cjca.2012.02.004" @default.
• W2037229788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22482397" @default.
• W2037229788 hasPublicationYear "2012" @default.
• W2037229788 type Work @default.
• W2037229788 sameAs 2037229788 @default.
• W2037229788 citedByCount "18" @default.
• W2037229788 countsByYear W20372297882013 @default.
• W2037229788 countsByYear W20372297882015 @default.
• W2037229788 countsByYear W20372297882017 @default.
• W2037229788 countsByYear W20372297882018 @default.
• W2037229788 countsByYear W20372297882021 @default.
• W2037229788 countsByYear W20372297882022 @default.
• W2037229788 countsByYear W20372297882023 @default.
• W2037229788 crossrefType "journal-article" @default.

• next